- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Glycoprotein 2 Antibody GP2/2569R / GP2 / ZAP75 [clone GP2/2569R] (V7279)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7279-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7279-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7279SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V7279IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | GP2/2569R |
| Purity | Protein A affinity chromatography |
| UniProt | P55259 |
| Localization | Cytoplasmic, membranous, secreted |
| Applications | ELISA : 2-4ug/ml (order BSA/azide-free format) Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT (1) |
| Limitations | This recombinant Glycoprotein 2 antibody is available for research use only. |
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Glycoprotein 2 (GP2), encoded by the GP2 gene, is a membrane-associated glycoprotein primarily localized to the membranes of pancreatic zymogen granules in acinar cells. Recombinant Glycoprotein 2 antibody GP2/2569R recognizes this secretory granule protein, which is commonly referred to as pancreatic secretory granule membrane major glycoprotein GP2 and zymogen granule membrane glycoprotein 2. GP2 is one of the most abundant proteins associated with pancreatic zymogen granule membranes and plays an important role in the secretory machinery of pancreatic acinar cells.
GP2 is synthesized in pancreatic acinar cells and becomes incorporated into the membranes of zymogen granules, which store digestive enzymes prior to secretion into the pancreatic ducts. During the regulated secretion process, these granules fuse with the apical plasma membrane and release their contents into the pancreatic ductal system. Glycoprotein 2 can subsequently be released into the pancreatic duct lumen where it may interact with luminal components. Due to this biology, GP2 expression is strongly associated with pancreatic acinar differentiation and secretory granule formation.
Recombinant Glycoprotein 2 antibody GP2/2569R is designed to detect GP2 protein expression in research applications focused on pancreatic tissue biology and epithelial differentiation. In tissue sections, Glycoprotein 2 expression is typically observed in pancreatic acinar cells, where the protein localizes to the apical cytoplasmic region corresponding to zymogen granules. This distinctive cellular distribution reflects the role of GP2 in digestive enzyme packaging and secretion. Detection of GP2 in tissue specimens therefore provides insight into the presence and integrity of pancreatic acinar cells within normal or diseased tissues.
Beyond its role in pancreatic secretion, GP2 has also been reported in certain epithelial and mucosal environments where it may participate in interactions between epithelial surfaces and microbial components. Some studies have suggested that GP2 can function as a receptor for bacterial structures and may contribute to mucosal immune surveillance in specialized epithelial cells. These findings indicate that GP2 may have broader biological roles beyond the pancreas, particularly in host defense mechanisms within epithelial tissues.
Recombinant Glycoprotein 2 antibody supports the detection of GP2 protein expression in research settings examining pancreatic physiology, epithelial cell differentiation, and secretory granule biology. Because GP2 expression is highly characteristic of pancreatic acinar cells, antibodies targeting this protein are frequently used to investigate pancreatic tissue organization and acinar cell identity. Analysis of GP2 expression patterns can therefore contribute to studies of pancreatic development, tissue differentiation, and disease-related alterations in secretory cell function.
Optimal dilution of the recombinant Glycoprotein 2 antibody GP2/2569R should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
A partial human recombinant protein corresponding to amino acids 35-179 was used as the immunogen for the recombinant Glycoprotein 2 antibody.
Store the recombinant Glycoprotein 2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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