- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
GLUL Antibody Recombinant Mouse MAb / Glutamine Synthetase [clone rGLUL/8620] (V4712)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4712-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4712-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4712SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rGLUL/8620 |
| Purity | Protein A/G affinity |
| UniProt | P15104 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This recombinant GLUL antibody is available for research use only. |
|
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Glutamate-ammonia ligase is a cytosolic enzyme encoded by the GLUL gene and commonly referred to as Glutamine synthetase. GLUL Antibody Recombinant Mouse MAb rGLUL/8620 is developed to detect this key metabolic enzyme, which catalyzes the ATP-dependent conversion of glutamate and ammonia into glutamine. This reaction is central to nitrogen metabolism, ammonia detoxification, and maintenance of intracellular glutamine pools. The GLUL gene is located on chromosome 1q31.3 and exhibits regulated, tissue-specific expression patterns.
Glutamine synthetase shows highly characteristic distribution in normal tissues. In the liver, expression is typically restricted to pericentral hepatocytes surrounding central veins, forming a distinct zonal pattern that reflects metabolic compartmentalization within the hepatic lobule. In the central nervous system, GLUL is enriched in astrocytes, where it supports the glutamate-glutamine cycle and contributes to neurotransmitter homeostasis. In these cells, the enzyme localizes to the cytoplasm and is distributed throughout the cell body and processes.
Expression can also be detected in kidney, skeletal muscle, and selected epithelial tissues depending on metabolic demand. In tumor biology, altered glutamine synthetase expression has been described in hepatocellular carcinoma and other malignancies, where GLUL upregulation may correlate with pathway activation and metabolic reprogramming. These distinct patterns make GLUL a valuable marker in studies examining metabolic zonation, astrocyte biology, and cancer-associated metabolic adaptation.
As a recombinant mouse monoclonal reagent, GLUL Antibody Recombinant Mouse MAb rGLUL/8620 provides defined target recognition with consistent performance across research applications. Positive cells typically demonstrate diffuse to granular cytoplasmic staining consistent with the known intracellular localization of glutamine synthetase. This antibody supports investigation of metabolic regulation and tissue-specific expression of GLUL in normal and disease contexts.
Optimal dilution of the GLUL antibody recombinant mouse mAb rGLUL/8620 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the GLUL antibody.
Aliquot the recombinant GLUL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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