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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Fatty Acid Binding Protein 1 Antibody Rabbit MAb clone FABP1/9085R recognizes Liver fatty acid binding protein, also known as FABP1 or L-FABP, a cytoplasmic lipid binding protein encoded by the FABP1 gene on chromosome 2p11.2. Liver fatty acid binding protein is abundantly expressed in hepatocytes and plays a central role in intracellular transport and metabolism of long chain fatty acids. FABP1 is a member of the fatty acid binding protein family, a group of small cytoplasmic proteins that regulate lipid trafficking and lipid mediated signaling pathways.
FABP1 contains a conserved beta barrel structure that forms a hydrophobic ligand binding pocket, enabling binding of long chain fatty acids, bile acids, eicosanoids, and other hydrophobic molecules. In hepatocytes, FABP1 facilitates fatty acid uptake, beta oxidation, triglyceride synthesis, and lipid storage. By buffering intracellular fatty acids, Liver fatty acid binding protein contributes to protection against lipotoxic stress and supports maintenance of hepatic metabolic homeostasis.
In normal tissues, FABP1 expression is strongest in liver, where it localizes to the cytoplasm of hepatocytes. Lower levels of expression are observed in kidney proximal tubule epithelium and small intestinal enterocytes. Because of its abundant and relatively tissue restricted expression, FABP1 antibody is frequently used in research applications to study hepatocellular differentiation, metabolic regulation, and liver disease models. Cytoplasmic staining in hepatocytes is the expected localization pattern.
Altered FABP1 expression has been associated with fatty liver disease, metabolic syndrome, and hepatocellular carcinoma. Changes in Liver fatty acid binding protein levels have been investigated in the context of lipid accumulation, oxidative stress, and liver injury. Fatty Acid Binding Protein 1 Antibody Rabbit MAb clone FABP1/9085R is suitable for detecting FABP1 expression in relevant research applications focused on hepatic biology and lipid metabolism.
Researchers interested in a broadly validated FABP1 antibody for lipid metabolism and fatty acid transport studies may also benefit from our HuProt-validated FABP1 antibody clone FABP1/3487, supported by western blot, immunohistochemistry, and protein microarray specificity data.
Optimal dilution of the Fatty Acid Binding Protein 1 antibody should be determined by the researcher.
A human recombinant FABP1 protein fragment (within amino acids 1-127) was used as the immunogen for the recombinant Fatty Acid Binding Protein 1 antibody rabbit mAb clone FABP1/9085R.
Aliquot the Fatty Acid Binding Protein 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Fatty acid-binding protein 1 antibody, Liver-type fatty acid-binding protein, FABP1 antibody, L-FABP antibody
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