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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
FABP1 Antibody Recombinant Mouse MAb / Fatty Acid Binding Protein 1 [clone rFABP1/8520] (V4873)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4873-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4873-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4873SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rFABP1/8520 |
| Purity | Protein A/G affinity |
| UniProt | P07148 |
| Localization | Cytoplasm, Nucleus |
| Applications | Western Blot : 2-4ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This FABP1 antibody is available for research use only. |
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FABP1 Antibody - Recombinant Mouse MAb rFABP1/8520 recognizes Liver fatty acid binding protein, also known as FABP1 or L-FABP, a cytoplasmic lipid binding protein encoded by the FABP1 gene on chromosome 2p11.2. Liver fatty acid binding protein is abundantly expressed in hepatocytes and functions as an intracellular lipid chaperone that regulates the uptake, trafficking, and metabolism of long chain fatty acids. FABP1 is a member of the fatty acid binding protein family, a group of small cytoplasmic proteins that coordinate lipid homeostasis and lipid mediated signaling pathways.
Structurally, FABP1 contains a conserved beta barrel motif that forms a hydrophobic ligand binding pocket. This configuration enables binding of long chain fatty acids, bile acids, eicosanoids, and other hydrophobic ligands, facilitating their solubilization and intracellular transport. In hepatocytes, FABP1 contributes to fatty acid uptake, beta oxidation, triglyceride synthesis, and protection against lipotoxic stress. Through these functions, Liver fatty acid binding protein plays an essential role in hepatic energy metabolism and regulation of lipid balance.
In normal tissues, FABP1 expression is strongest in liver, where it localizes to the cytoplasm of hepatocytes. Lower levels of expression are observed in kidney proximal tubule epithelium and small intestinal enterocytes. Because of its abundant and relatively tissue restricted distribution, FABP1 antibody is widely used in research to study hepatocellular differentiation, metabolic regulation, and liver associated disease models. Cytoplasmic staining in hepatocytes represents the expected localization pattern.
Altered FABP1 expression has been associated with fatty liver disease, metabolic syndrome, and hepatocellular carcinoma. Changes in Liver fatty acid binding protein levels have been investigated in the context of lipid accumulation, oxidative stress, and liver injury. FABP1 Antibody - Recombinant Mouse MAb rFABP1/8520 is suitable for detecting FABP1 expression in relevant research applications focused on hepatic biology and lipid metabolism.
Optimal dilution of the FABP1 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-127) from the human protein was used as the immunogen for the FABP1 antibody recombinant mouse mAb rFABP1/8520.
Aliquot the FABP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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