- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant ErbB2 antibody detects ErbB2, also known as HER2, a receptor tyrosine kinase encoded by the ERBB2 gene. ErbB2 is a member of the epidermal growth factor receptor family and functions as a preferred dimerization partner for other ErbB receptors. Because ErbB2 amplification drives tumorigenesis in breast and gastric cancers, Recombinant ErbB2 antibody is indispensable in oncology, pathology, and therapeutic development.
ErbB2 consists of an extracellular receptor domain, a single transmembrane helix, and an intracellular tyrosine kinase domain. While ErbB2 lacks a direct ligand, its heterodimerization with EGFR and ErbB3 activates signaling cascades including MAPK, PI3K/AKT, and STAT pathways. These pathways regulate proliferation, differentiation, angiogenesis, and survival. Overexpression of ErbB2 is a well-established predictor of aggressive tumor biology and targeted therapy responsiveness.
The Recombinant ErbB2 antibody clone ERBB2/4376R provides specific and reproducible recognition. Recombinant technology ensures consistent performance across batches, minimizing variability. Clone ERBB2/4376R has been referenced in peer-reviewed publications investigating breast carcinoma, gastric adenocarcinoma, and receptor tyrosine kinase signaling. Its versatility makes it suitable for immunohistochemistry, immunoblotting, and flow cytometry.
Research using clone ERBB2/4376R has highlighted how ErbB2 overexpression correlates with poor prognosis in breast and gastric cancers. In translational research, ErbB2 detection has guided the development and clinical use of monoclonal antibodies and kinase inhibitors, transforming oncology practice. This antibody has also supported mechanistic studies of dimerization, receptor trafficking, and signaling regulation in cancer biology.
NSJ Bioreagents provides this Recombinant ErbB2 antibody to support oncology, receptor biology, and therapeutic development research. Alternate designations include HER2 antibody, neu oncogene protein antibody, epidermal growth factor receptor 2 antibody, receptor tyrosine kinase ErbB2 antibody, and breast cancer marker antibody.
Optimal dilution of the recombinant ErbB2 antibody should be determined by the researcher.
Recombinant extracellular domain of human c-erbB2/HER2 was used as the immunogen for the recombinant ErbB2 antibody.
Aliquot the recombinant ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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