- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
EGF Receptor / EGFR Antibody / Extracellular domain [clone rEGFR/6389] (V9273)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9273-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9273-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9273SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rEGFR/6389 |
| Purity | Protein A/G affinity |
| UniProt | P00533 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant EGF Receptor antibody is available for research use only. |
|
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EGF Receptor Antibody recognizes Epidermal growth factor receptor, a membrane-spanning receptor tyrosine kinase that mediates cellular responses to epidermal growth factor and related ligands. Epidermal growth factor receptor, also widely referred to as EGFR, ErbB1, and HER1, functions as a key regulator of epithelial cell growth, survival, and differentiation through ligand-induced receptor activation. EGF Receptor Antibody is used in research settings to examine receptor expression and distribution in normal tissues and disease models where growth factor signaling is biologically relevant. The EGF receptor protein is predominantly localized to the plasma membrane, consistent with its role in ligand binding and signal initiation.
Epidermal growth factor receptor is encoded by the EGFR gene and undergoes dimerization and autophosphorylation following ligand engagement, leading to activation of downstream signaling pathways including MAPK, PI3K-AKT, and STAT cascades. These pathways coordinate cellular proliferation, survival, and adaptive responses to environmental cues. EGF Receptor Antibody enables investigation of EGFR expression levels and cellular localization, supporting studies of growth factor-driven signaling networks and epithelial biology across diverse experimental systems.
Dysregulation of EGF receptor signaling is a central feature of multiple cancers, where overexpression, amplification, or mutation of EGFR contributes to uncontrolled cell growth and altered differentiation. As a result, Epidermal growth factor receptor is extensively studied in oncology-focused research involving lung, colorectal, head and neck, and brain tumors. EGF Receptor Antibody supports research into receptor-associated tumor biology, comparative expression analysis, and signaling pathway alterations without implying clinical or diagnostic use.
Beyond cancer biology, EGFR signaling also plays important roles in tissue development, regeneration, and wound repair. Modulation of EGF receptor activity influences epithelial maintenance and response to injury in multiple organ systems. EGF Receptor Antibody provides a valuable tool for examining EGFR expression patterns and membrane-associated signaling behavior in both normal and disease-related research contexts. Clone rEGFR/6389 is designed to recognize Epidermal growth factor receptor and may be applied to studies of growth factor signaling, receptor biology, and epithelial cell regulation.
Optimal dilution of the recombinant EGF Receptor antibody should be determined by the researcher.
Amino acids 25-645 from the extracellular domain of the human protein were used as the immunogen for the recombinant EGF Receptor antibody.
Aliquot the recombinant EGF Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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