- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant E-Cadherin antibody detects E-cadherin, a calcium-dependent adhesion glycoprotein encoded by the CDH1 gene. E-cadherin is expressed in epithelial tissues, where it maintains cell-cell adhesion, polarity, and tissue architecture. Loss or dysfunction of E-cadherin is a hallmark of epithelial-mesenchymal transition and cancer progression. Because of its roles in adhesion and tumor suppression, Recombinant E-Cadherin antibody is widely used in oncology, developmental biology, and pathology.
E-cadherin consists of five extracellular cadherin repeats, a single transmembrane domain, and a cytoplasmic tail that interacts with catenins. This interaction links cadherins to the actin cytoskeleton, stabilizing junctions and regulating signaling pathways. Proper expression of E-cadherin maintains epithelial barrier integrity, while reduced expression promotes invasiveness and metastasis in carcinomas.
The Recombinant E-Cadherin antibody clone CDH1/4398R provides consistent and specific detection. Recombinant production ensures reproducibility across batches, minimizing variability. Clone CDH1/4398R has been cited in peer-reviewed studies exploring EMT, cancer biology, and epithelial differentiation. It is suitable for immunohistochemistry, Western blotting, and immunofluorescence.
Research using clone CDH1/4398R has shown how E-cadherin loss correlates with poor prognosis in breast, gastric, and colorectal cancers. Detection with this antibody supports diagnostic pathology by distinguishing epithelial tumors from non-epithelial neoplasms. Beyond oncology, studies have used this antibody to examine epithelial barrier function in inflammation and developmental processes that require dynamic regulation of adhesion.
NSJ Bioreagents provides this Recombinant E-Cadherin antibody to support oncology, pathology, and epithelial biology research. Alternate terms include CDH1 antibody, cadherin-1 antibody, epithelial cadherin antibody, uvomorulin antibody, epithelial tumor suppressor antibody, and calcium-dependent adhesion glycoprotein antibody.
Optimal dilution of the recombinant E-Cadherin antibody should be determined by the researcher.
A portion of amino acids 600-700 from the human protein was used as the immunogen for the recombinant E-Cadherin antibody.
Store the recombinant E-Cadherin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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