- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant dsDNA Antibody [clone rDSD/4565] (V8639)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8639-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
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V8639-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V8639SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rDSD/4565 |
| Purity | Protein G affinity chromatography |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Immunofluorescence : 1-3ug/ml |
| Limitations | This recombinant dsDNA antibody is available for research use only. |
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Recombinant dsDNA antibody detects double-stranded DNA, the canonical genetic material found in eukaryotes, prokaryotes, and many viruses. Unlike protein-specific antibodies, dsDNA antibodies recognize DNA structures independent of sequence, making them valuable for immunology, autoimmunity, and molecular biology research. Because dsDNA antibodies are hallmarks of systemic lupus erythematosus and other autoimmune conditions, Recombinant dsDNA antibody is widely used in both clinical and basic studies.
Double-stranded DNA is composed of complementary strands of nucleotides paired through hydrogen bonds between adenine-thymine and cytosine-guanine bases. Its helical structure stores genetic information and serves as the template for replication and transcription. In pathology, antibodies against dsDNA are considered highly specific for lupus and are used diagnostically as markers of disease activity.
The Recombinant dsDNA antibody clone rDSD/4565 provides consistent and reproducible recognition of double-stranded DNA. Recombinant technology ensures lot-to-lot uniformity, reducing variability in assays. Clone rDSD/4565 has been cited in peer-reviewed research examining lupus autoantibodies, DNA repair mechanisms, and chromatin biology. Its versatility supports use in ELISA, immunofluorescence, and molecular assays that require DNA detection.
Research using clone rDSD/4565 has clarified how anti-dsDNA antibodies participate in lupus pathogenesis, forming immune complexes that deposit in tissues and trigger inflammation. This antibody has also been applied in studies of DNA stability, chromatin structure, and cell death, where dsDNA release serves as a damage-associated molecular pattern. Its broad utility makes it a valuable tool across both clinical immunology and molecular biology.
NSJ Bioreagents provides this Recombinant dsDNA antibody to support autoimmunity research, molecular biology, and clinical diagnostics. Alternate terms include double-stranded DNA antibody, lupus autoantibody marker antibody, chromatin component antibody, DNA helix antibody, and genomic DNA antibody.
Optimal dilution of the recombinant dsDNA antibody should be determined by the researcher.
Nuclei of Burkitt cells were used as the immunogen for the recombinant dsDNA antibody.
Store the recombinant dsDNA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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