Desmocollin-2/3 Antibody - Desmosomal Adhesion and Epithelial Integrity Marker [clone DSC2/9165R] (V5579)

Desmocollin-2/3 Antibody Intestine and Stomach WB. Western blot analysis of human intestine and human stomach lysates using a recombinant monoclonal Desmocollin-2/3 antibody detecting DSC2 and DSC3, clone DSC2/9165R. A band is detected at approximately 95-110 kDa in both samples, consistent with the expected molecular weight of desmocollin proteins. This size range reflects glycosylation and processing typical of these desmosomal cadherins, which are key components of epithelial cell-cell adhesion complexes that maintain tissue integrity in gastrointestinal epithelium.

SDS-PAGE analysis of purified, BSA-free recombinant Desmocollin-2/3 antibody (clone DSC2/9165R) as confirmation of integrity and purity.

Desmocollin-2/3 Antibody Esophagus IHC. Immunohistochemistry analysis of FFPE human esophagus tissue stained with a recombinant monoclonal Desmocollin-2/3 antibody detecting DSC2 and DSC3, clone DSC2/9165R. Strong membranous staining is observed in stratified squamous epithelial cells, highlighting desmosomal junctions that mediate robust cell-cell adhesion and preserve epithelial structural integrity. Signal is most prominent along cell borders within basal and suprabasal layers, consistent with the role of desmocollins as core adhesion molecules in stratified epithelia, while surrounding stromal regions remain largely negative. The inset shows a PBS-only negative control processed without primary antibody, confirming minimal non-specific background staining. Hematoxylin counterstain highlights nuclei in blue. HIER: boil tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.