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Home >> Antibodies >> DCN Antibody Recombinant Mouse MAb / Decorin

DCN Antibody Recombinant Mouse MAb / Decorin [clone rDCN/9075] (V4313)

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  Catalog No Formulation Size Price (USD)  
Image V4313-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V4313-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V4313SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated Recmousemono
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Immunohistochemistry of DCN antibody in human prostate carcinoma tissue. Formalin-fixed, paraffin-embedded human prostate carcinoma was stained using recombinant mouse monoclonal DCN antibody (clone rDCN/9075). Heat induced epitope retrieval was performed by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 20 min followed by cooling prior to staining. HRP-DAB brown chromogenic signal highlights extracellular stromal matrix surrounding malignant glands, consistent with Decorin localization within collagen-rich connective tissue. The inset shows PBS used in place of primary antibody as a secondary-only negative control.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG2b, kappa
Clone Name rDCN/9075
Purity Protein A/G affinity
UniProt P07585
Localization Secreted
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This DCN antibody is available for research use only.
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Description

DCN Antibody Recombinant Mouse MAb detects Decorin, a small leucine-rich extracellular matrix proteoglycan encoded by the DCN gene and broadly expressed in connective tissues. Clone rDCN/9075 is a recombinant mouse monoclonal antibody developed for consistent research performance and supports evaluation of stromal matrix organization and collagen-associated structures in tissue specimens.

DCN antibody, also referred to as Decorin antibody and small leucine-rich proteoglycan decorin antibody in the literature, recognizes a secreted proteoglycan characterized by tandem leucine-rich repeat domains and a single glycosaminoglycan side chain. Decorin binds to fibrillar collagens, particularly type I collagen, where it regulates collagen fibrillogenesis, fiber spacing, and matrix assembly. Through these interactions, Decorin contributes to tensile strength, extracellular matrix stability, and proper tissue architecture.

In addition to structural functions, Decorin modulates cell signaling pathways by interacting with growth factors and receptor tyrosine kinases, including transforming growth factor beta and epidermal growth factor receptor. These interactions influence cell proliferation, migration, and differentiation, positioning Decorin as both a structural and regulatory matrix component. DCN expression is prominent in skin, tendon, ligament, cornea, prostate stroma, and placental connective tissue. In tissue-based analyses, Decorin typically demonstrates extracellular stromal staining localized between collagen bundles and within connective tissue frameworks.

Altered Decorin expression has been implicated in fibrotic disorders, abnormal wound healing, and tumor progression, where extracellular matrix composition influences cellular behavior and microenvironmental signaling. Reduced or redistributed Decorin may be associated with desmoplastic stroma or altered collagen organization in malignancy. A DCN Antibody Recombinant Mouse MAb such as clone rDCN/9075 supports investigations into extracellular matrix biology, stromal-tumor interactions, fibrosis research, and connective tissue development. This antibody targets Decorin in research applications and is available from NSJ Bioreagents.

Application Notes

Optimal dilution of the DCN antibody recombinant mouse mAb should be determined by the researcher.

For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

Immunogen

A recombinant human Decorin protein fragment (within amino acids 200-359) was used as the immunogen for the DCN antibody recombinant mouse mAb.

Storage

Aliquot the DCN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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