- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Cytokeratin 8/18 Antibody [clone KRT8.18/2297R] (V8405)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8405-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8405-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8405SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | KRT8.18/2297R |
| Purity | Protein A affinity chromatography |
| UniProt | P05787 , P05783 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This recombinant Cytokeratin 8/18 antibody is available for research use only. |
|
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Recombinant Cytokeratin 8/18 antibody detects cytokeratins 8 and 18, type II and type I intermediate filament proteins encoded by the KRT8 and KRT18 genes. These proteins are co-expressed in simple epithelial tissues, forming obligate heteropolymers that provide structural integrity and resilience. Because cytokeratin 8 and cytokeratin 18 are widely used as epithelial lineage markers and indicators of tissue pathology, Recombinant Cytokeratin 8/18 antibody is an important tool in oncology, pathology, and epithelial biology.
Cytokeratin 8 is a type II keratin, while cytokeratin 18 is a type I keratin. Together they form filament networks that stabilize epithelial cells against mechanical stress. Beyond structural roles, these proteins participate in apoptosis, signal transduction, and cell cycle regulation. Aberrant expression of keratins 8 and 18 has been linked to carcinomas, liver disease, and inflammatory conditions, making them valuable diagnostic and prognostic biomarkers.
The Recombinant Cytokeratin 8/18 antibody clone KRT8.18/2297R provides reproducible and specific recognition of both keratins. Recombinant technology ensures lot-to-lot uniformity, which is critical for long-term studies. Clone KRT8.18/2297R has been cited in peer-reviewed studies investigating liver pathology, breast carcinoma, and epithelial differentiation. Its applications include immunohistochemistry, Western blotting, and cytological analysis.
Research using clone KRT8.18/2297R has shown how cytokeratins 8 and 18 are upregulated in carcinomas compared to normal tissues, providing diagnostic discrimination from non-epithelial tumors. In hepatology, these keratins are released into the serum during cell injury, and their detection has been associated with progression of liver disease. In oncology, keratin 8 and 18 staining is a standard component of panels that identify epithelial tumor origin, supporting accurate pathology classification.
NSJ Bioreagents supplies this Recombinant Cytokeratin 8/18 antibody to support oncology, pathology, and epithelial research. Alternate names include KRT8 antibody, KRT18 antibody, keratin type II cytoskeletal 8 antibody, keratin type I cytoskeletal 18 antibody, simple epithelial keratin antibody, and epithelial intermediate filament antibody.
Researchers studying the K8/K18 intermediate filament system can explore our Cytokeratin 8/18 Antibody page for additional reagents targeting these widely expressed epithelial keratins.
Optimal dilution of the recombinant Cytokeratin 8/18 antibody should be determined by the researcher.
1. Immunohistochemical staining with this MAb is indistinguishable from that obtained with monoclonal antibody 5D3.
Recombinant full-length human KRT8/18 protein was used as the immunogen for the recombinant Cytokeratin 8/18 antibody.
Store the recombinant Cytokeratin 8/18 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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