- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant Cytokeratin 8/18 Antibody [clone KRT8.18/2297R] (V8405)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8405-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
|
V8405-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
|
|
V8405SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | KRT8.18/2297R |
| Purity | Protein A affinity chromatography |
| UniProt | P05787 , P05783 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This recombinant Cytokeratin 8/18 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Recombinant Cytokeratin 8/18 antibody detects cytokeratins 8 and 18, type II and type I intermediate filament proteins encoded by the KRT8 and KRT18 genes. These proteins are co-expressed in simple epithelial tissues, forming obligate heteropolymers that provide structural integrity and resilience. Because cytokeratin 8 and cytokeratin 18 are widely used as epithelial lineage markers and indicators of tissue pathology, Recombinant Cytokeratin 8/18 antibody is an important tool in oncology, pathology, and epithelial biology.
Cytokeratin 8 is a type II keratin, while cytokeratin 18 is a type I keratin. Together they form filament networks that stabilize epithelial cells against mechanical stress. Beyond structural roles, these proteins participate in apoptosis, signal transduction, and cell cycle regulation. Aberrant expression of keratins 8 and 18 has been linked to carcinomas, liver disease, and inflammatory conditions, making them valuable diagnostic and prognostic biomarkers.
The Recombinant Cytokeratin 8/18 antibody clone KRT8.18/2297R provides reproducible and specific recognition of both keratins. Recombinant technology ensures lot-to-lot uniformity, which is critical for long-term studies. Clone KRT8.18/2297R has been cited in peer-reviewed studies investigating liver pathology, breast carcinoma, and epithelial differentiation. Its applications include immunohistochemistry, Western blotting, and cytological analysis.
Research using clone KRT8.18/2297R has shown how cytokeratins 8 and 18 are upregulated in carcinomas compared to normal tissues, providing diagnostic discrimination from non-epithelial tumors. In hepatology, these keratins are released into the serum during cell injury, and their detection has been associated with progression of liver disease. In oncology, keratin 8 and 18 staining is a standard component of panels that identify epithelial tumor origin, supporting accurate pathology classification.
NSJ Bioreagents supplies this Recombinant Cytokeratin 8/18 antibody to support oncology, pathology, and epithelial research. Alternate names include KRT8 antibody, KRT18 antibody, keratin type II cytoskeletal 8 antibody, keratin type I cytoskeletal 18 antibody, simple epithelial keratin antibody, and epithelial intermediate filament antibody.
Immunohistochemical staining with this MAb is indistinguishable from that obtained with monoclonal antibody 5D3.
Optimal dilution of the recombinant Cytokeratin 8/18 antibody should be determined by the researcher.
Recombinant full-length human KRT8/18 protein was used as the immunogen for the recombinant Cytokeratin 8/18 antibody.
Store the recombinant Cytokeratin 8/18 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
Citations(7)