- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cytokeratin 6A Antibody / KRT6A [clone rKRT6A/2100] (V7912)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7912-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V7912-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V7912SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rKRT6A/2100 |
| Purity | Protein G affinity chromatography |
| UniProt | P02538 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant Cytokeratin 6A antibody is available for research use only. |
|
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Cytokeratin 6A antibody recognizes Cytokeratin 6A/KRT6A, a type II intermediate filament protein encoded by the KRT6A gene that belongs to the keratin family of cytoskeletal proteins. Cytokeratin 6A is a member of the high-molecular-weight keratin subgroup and is closely related to Cytokeratin 6B and Cytokeratin 6C, with overlapping but distinct expression patterns. In normal human tissues, Cytokeratin 6A is minimally expressed in most mature epithelia but is rapidly induced in stratified squamous epithelia under conditions of stress, injury, inflammation, or hyperproliferation. As such, a Cytokeratin 6A antibody is widely used to study epithelial activation, wound healing responses, and stress-associated keratin reprogramming.
Cytokeratin 6A antibody, also referred to as KRT6A antibody or Keratin 6A antibody in the literature, is particularly relevant in dermatologic and epithelial biology. Cytokeratin 6A is strongly upregulated in hyperproliferative keratinocytes, including those found in psoriasis, chronic wounds, and regenerative epidermis. At the cellular level, Cytokeratin 6A localizes to the cytoplasm where it integrates into the intermediate filament network, contributing to mechanical resilience and cellular adaptation during rapid epithelial turnover.
In cancer biology, Cytokeratin 6A antibody is frequently used as a marker of squamous differentiation and basal-like epithelial phenotypes. Elevated Cytokeratin 6A expression has been reported in squamous cell carcinomas of the skin, lung, head and neck, cervix, and esophagus, as well as in subsets of basal-like carcinomas. Because Cytokeratin 6A expression reflects altered differentiation and increased proliferative capacity, detection of this protein can provide valuable contextual information in tumor classification and epithelial lineage assessment. Recombinant Cytokeratin 6A antibody reagents offer consistency and specificity for detecting KRT6A expression across diverse research applications, supporting studies of epithelial biology, disease progression, and tissue remodeling.
Optimal dilution of the recombinant Cytokeratin 6A antibody should be determined by the researcher.
A recombinant full-length human Cytokeratin 6A protein was used as the immunogen for this recombinant Cytokeratin 6A antibody.
Store the recombinant Cytokeratin 6A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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