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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Cyclin E1 Antibody / CCNE1 [clone rCCNE1/4936] (V9151)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9151-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9151-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9151SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rCCNE1/4936 |
| Purity | Protein A/G affinity |
| UniProt | IDP24864 |
| Localization | Nuclear |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Cyclin E1 antibody is available for research use only. |
|
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Cyclin E1 antibody recognizes Cyclin E1, a key cell cycle regulatory protein encoded by the CCNE1 gene. Also known as G1-S specific cyclin E1, this nuclear protein forms an active complex with cyclin-dependent kinase 2 and drives progression from the G1 phase into S phase of the cell cycle. Cyclin E1 antibody is widely used in research investigating cell proliferation, DNA replication control, and tumor-associated cell cycle dysregulation.
Cyclin E1 accumulates during late G1 phase and reaches peak expression at the G1-S transition, where it promotes phosphorylation of downstream substrates required for initiation of DNA synthesis. The protein contains conserved cyclin box domains that mediate binding to CDK2 and regulate kinase activation. Cyclin E1 is predominantly localized to the nucleus, reflecting its role in coordinating replication origin firing and S phase entry. Tight regulation of CCNE1 expression and proteasomal degradation ensures proper cell cycle timing and genomic stability.
Amplification or overexpression of CCNE1 has been reported in multiple malignancies, including ovarian, breast, lung, and gastric cancers. Elevated Cyclin E1 levels are often associated with increased proliferation rates, genomic instability, and poor clinical prognosis in certain tumor types. Immunostaining typically demonstrates strong nuclear localization in actively cycling cells. Clone rCCNE1/4936 is a recombinant mouse monoclonal antibody generated through defined sequence expression to support lot-to-lot consistency and reproducible performance. This Cyclin E1 antibody enables investigation of cell cycle regulation, tumor biology, and proliferation status in research applications.
Optimal dilution of the Cyclin E1 antibody should be determined by the researcher.
A portion of amino acids 10-176 was used as the immunogen for the Cyclin E1 antibody.
Aliquot the Cyclin E1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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