- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Collagen IV Antibody Rabbit Monoclonal / COL4A [clone COL4/4241R] (V8505)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8505-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8505-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V8505SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | COL4/4241R |
| Purity | Protein A affinity chromatography |
| UniProt | P02462 |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This Collagen IV antibody is available for research use only. |
|
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Collagen IV Antibody Rabbit Monoclonal detects Collagen type IV, a major structural component of basement membranes and an essential element of the extracellular matrix. This rabbit monoclonal antibody recognizes Collagen IV in research applications and supports evaluation of basement membrane integrity, vascular architecture, and epithelial-stromal interfaces in tissue models.
Collagen IV antibody, also referred to as Type IV collagen antibody and COL4A antibody in the literature, targets network-forming collagen chains encoded by genes including COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, and COL4A6. Unlike fibrillar collagens, Collagen IV assembles into a sheet-like scaffold within basement membranes, forming a structural framework that interacts with laminins, nidogens, and heparan sulfate proteoglycans. These interactions regulate cell adhesion, migration, differentiation, and barrier function across multiple organ systems.
Collagen IV is widely distributed in vascular basement membranes, kidney glomeruli, lung alveolar septa, skeletal muscle endomysium, and epithelial basement membrane zones throughout the body. In tissue-based studies, Collagen IV typically demonstrates linear staining along basement membranes, outlining blood vessels, glands, and epithelial layers. This pattern makes a Collagen IV Antibody Rabbit Monoclonal valuable for investigations of angiogenesis, tumor invasion, extracellular matrix remodeling, and developmental tissue organization.
Alterations in Collagen IV composition or distribution are associated with renal disorders, cerebrovascular abnormalities, and cancer progression, where basement membrane disruption facilitates invasion. A Collagen IV Antibody Rabbit Monoclonal can therefore assist in research focused on extracellular matrix biology, epithelial-mesenchymal transition, and microenvironmental changes in disease models. This antibody targets Collagen IV in research applications and is available from NSJ Bioreagents.
Optimal dilution of the Collagen IV antibody rabbit monoclonal should be determined by the researcher.
Purified human placental extract was used as the immunogen for the Collagen IV antibody rabbit monoclonal.
Store the Collagen IV antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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