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Home >> Antibodies >> Recombinant CLIP Antibody / ACTH

Recombinant CLIP Antibody / ACTH [clone CLIP/2859R] (V8018)

  Catalog No Formulation Size Price (USD)  
Image V8018-100UG 0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 429
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V8018-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 199
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V8018SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 429
SDS-PAGE analysis of purified, BSA-free recombinant CLIP antibody (clone CLIP/2859R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name CLIP/2859R
Purity Protein A affinity chromatography
UniProt P01189
Applications ELISA (order BSA-free format for coating) :
Limitations This recombinant CLIP antibody is available for research use only.
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Description

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to CLIP (aa25-39 of ACTH); does not react with Synacthen (aa1-24 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

Application Notes

Optimal dilution of the recombinant CLIP antibody should be determined by the researcher.

Immunogen

Amino acids 25-39 (NGAEDESAEAFPLEF) from human ACTH were used as the immunogen for this recombinant CLIP antibody.

Storage

Store the recombinant CLIP antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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