- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant CgA Antibody / Chromogranin A [clone rCHGA/9612] (V5459)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5459-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V5459-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5459SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | rCHGA/9612 |
| Purity | Protein A/G affinity |
| UniProt | P10645 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant CgA antibody is available for research use only. |
|
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Recombinant CgA Antibody recognizes Chromogranin A, a secretory granule protein encoded by the CHGA gene and widely used as a marker of neuroendocrine differentiation. Chromogranin A is an acidic glycoprotein localized to the cytoplasm of endocrine and neuroendocrine cells, where it is stored within dense-core secretory granules. A Recombinant CgA Antibody is suitable for research applications focused on detecting Chromogranin A expression in formalin-fixed, paraffin-embedded tissues and other experimental systems evaluating neuroendocrine biology.
CgA antibody, also referred to as Chromogranin A antibody and CHGA antibody in the literature, targets a member of the granin protein family. Chromogranin A functions in granule biogenesis, hormone packaging, and regulated secretion within the trans-Golgi network and secretory vesicles. Proteolytic processing of Chromogranin A generates several biologically active peptides, including vasostatin, pancreastatin, and catestatin, which contribute to modulation of cardiovascular tone, metabolic regulation, and neuroendocrine signaling pathways.
CHGA is highly expressed in adrenal medulla chromaffin cells, pancreatic islet cells, gastrointestinal enteroendocrine cells, parathyroid tissue, and dispersed neuroendocrine cells throughout multiple organ systems. The expected immunohistochemical pattern is cytoplasmic granular staining corresponding to secretory vesicle localization. Because of this restricted lineage expression profile, Chromogranin A serves as a robust research marker for identifying neuroendocrine cells and tumors.
In tumor research, Chromogranin A expression is commonly evaluated in neuroendocrine neoplasms such as carcinoid tumors, pancreatic neuroendocrine tumors, small cell carcinoma, medullary thyroid carcinoma, and pheochromocytoma. Strong cytoplasmic staining supports neuroendocrine differentiation, whereas most non-neuroendocrine carcinomas demonstrate limited or absent expression. A Recombinant CgA Antibody therefore plays an important role in studies investigating tumor classification, differentiation status, and neuroendocrine pathway activity.
The rCHGA/9612 antibody is generated by expression in mammalian cells to provide consistent performance and lot-to-lot reproducibility for research use at NSJ Bioreagents.
Optimal dilution of the recombinant CgA antibody should be determined by the researcher.
Recombinant full-length human Chromogranin A protein was used as the immunogen for the recombinant CgA antibody.
Aliquot the recombinant CgA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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