- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CFTR Antibody for IHC / Immunohistochemistry Antibody [clone CFTR/7003R] (V9382)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9382-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9382-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9382SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CFTR/7003R |
| Purity | Protein A/G affinity |
| UniProt | P13569 |
| Localization | Cell surface, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CFTR Antibody for IHC / Immunohistochemistry Antibody is available for research use only. |
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Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane-associated ATP-binding cassette transporter that functions as a cAMP-regulated chloride and bicarbonate channel in epithelial tissues. Cystic fibrosis transmembrane conductance regulator (CFTR) is primarily localized to the apical membrane of polarized epithelial cells lining organs such as the airway, pancreas, salivary glands, intestine, and biliary system, where it plays a central role in fluid secretion and mucosal hydration. CFTR Antibody for IHC / Immunohistochemistry Antibody is particularly suited for visualizing CFTR distribution in formalin-fixed, paraffin-embedded tissue sections, enabling direct assessment of epithelial ion channel localization within intact tissue architecture. For a widely cited CFTR antibody used across multiple study types, see our M3A7 clone.
CFTR antibody, also referred to as cystic fibrosis transmembrane conductance regulator antibody or ABCC7 antibody, recognizes a large multi-domain protein composed of two nucleotide-binding domains, a regulatory domain, and multiple transmembrane segments that form the ion channel pore. CFTR activity is tightly controlled by phosphorylation and ATP binding, which regulate channel gating and ion conductance. In immunohistochemistry applications, CFTR is typically detected with apical membranous and luminal staining in epithelial cells, particularly within ductal and glandular structures, reflecting its physiological role in directing ion transport across epithelial surfaces.
This CFTR Antibody for IHC / Immunohistochemistry Antibody is optimized for tissue-based detection, providing clear visualization of CFTR localization relative to epithelial organization. Immunohistochemical staining highlights polarized expression patterns that distinguish epithelial compartments from surrounding stromal and immune cell populations. This spatial resolution is particularly valuable in tissues such as pancreas and salivary gland, where CFTR expression is concentrated in ductal epithelium, as well as in airway and intestinal tissues where epithelial transport function is critical. The ability to visualize CFTR in situ supports detailed analysis of tissue morphology, epithelial polarity, and glandular structure.
Mutations in CFTR are the underlying cause of cystic fibrosis, a genetic disorder characterized by defective chloride transport, impaired mucociliary clearance, and accumulation of viscous secretions. The most common mutation, delta F508, results in misfolding and defective trafficking of CFTR, leading to reduced apical membrane localization. These alterations can be assessed at the tissue level using immunohistochemistry, where changes in CFTR distribution and intensity provide insight into disease pathology. CFTR localization patterns are therefore highly relevant for studies of epithelial dysfunction and therapeutic response in cystic fibrosis and related conditions.
In addition to its role in cystic fibrosis, CFTR contributes to broader epithelial biology through regulation of other ion channels, vesicle trafficking, and epithelial differentiation. Altered CFTR expression has been reported in certain cancers and inflammatory conditions, where disruption of epithelial polarity and ion transport may influence disease progression. Its distinct apical localization and strong association with glandular and ductal epithelium make CFTR particularly well suited for immunohistochemical analysis. A CFTR antibody for IHC can be used to evaluate CFTR expression and localization in epithelial tissues and disease models, supporting investigations into ion transport, epithelial organization, and CFTR-associated pathology.
This antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the CFTR Antibody for IHC / Immunohistochemistry Antibody should be determined by the researcher.
A portion of amino acids 550-850 was used as the immunogen for the recombinant CFTR antibody.
Aliquot the CFTR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
CFTR antibody, Cystic fibrosis transmembrane conductance regulator antibody, ABCC7 antibody, CFTR IHC antibody, CFTR immunohistochemistry antibody
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