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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CELA3B Antibody Recombinant Mouse MAb / Elastase 3B [clone rCELA3B/1811] (V7811)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7811-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V7811-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7811SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rCELA3B/1811 |
| Purity | Protein G affinity chromatography |
| UniProt | P08861 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CELA3B antibody is available for research use only. |
|
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CELA3B Antibody Recombinant Mouse MAb rCELA3B/1811 is directed against Chymotrypsin-like elastase family member 3B, a secreted digestive serine protease commonly known as pancreatic elastase 3B or elastase 3B. The human CELA3B gene resides on chromosome 1p36.12 and encodes a protein that is highly enriched in pancreatic acinar cells, where it functions as part of the exocrine enzyme repertoire responsible for protein digestion. As a member of the elastase subfamily within the chymotrypsin-like serine protease family, CELA3B contributes to the regulated proteolytic environment of the small intestine.
The CELA3B protein is synthesized as a preproenzyme containing a signal peptide that directs entry into the endoplasmic reticulum, followed by a propeptide segment that maintains the enzyme in an inactive zymogen state. After processing in the Golgi apparatus, it is packaged into cytoplasmic zymogen granules within pancreatic acinar cells. Upon physiologic stimulation, these granules undergo exocytosis, releasing elastase 3B into the duodenal lumen where activation enables hydrolysis of dietary peptide substrates. Structurally, the mature enzyme adopts the conserved serine protease fold with a catalytic triad typical of trypsin-like endopeptidases.
CELA3B shares significant sequence and functional similarity with CELA3A, and both enzymes are sometimes referenced in the context of fecal elastase 1 measurement due to their stability in pancreatic secretions. In tissue-based research, CELA3B expression is largely restricted to pancreatic acinar cells, where it demonstrates strong cytoplasmic localization consistent with secretory granules. This restricted expression pattern supports its use as a lineage-associated marker of acinar differentiation and in studies evaluating pancreatic acinar cell carcinoma and other exocrine pancreatic neoplasms.
Genetic investigations have linked certain CELA3B variants to hereditary pancreatitis phenotypes, emphasizing the importance of tightly controlled protease activation in pancreatic homeostasis. Dysregulated digestive enzyme activity is a well-established contributor to pancreatitis pathogenesis. The recombinant mouse monoclonal clone rCELA3B/1811 is developed to support research applications focused on pancreatic acinar biology, digestive enzyme regulation, and elastase family protein expression.
Optimal dilution of the CELA3B antibody should be determined by the researcher.
Amino acids 82-238 from the human protein were used as the immunogen for the CELA3B antibody recombinant mouse mAb rCELA3B/1811.
Store the CELA3B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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