- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
Recombinant CD8A antibody is designed to detect CD8 alpha, a transmembrane glycoprotein expressed on cytotoxic T lymphocytes. CD8A pairs with CD8 beta to form a heterodimeric coreceptor that stabilizes interactions between the T cell receptor and peptide MHC class I complexes. This association enhances antigen recognition and ensures effective immune surveillance against virally infected and malignant cells. Because of its critical role in adaptive immunity, CD8A is a widely studied marker in immunology and oncology.
Structurally, CD8A is composed of an extracellular immunoglobulin like domain, a transmembrane region, and a cytoplasmic tail. Its interaction with MHC class I molecules strengthens T cell receptor engagement, while its intracellular region links to kinases such as Lck to amplify downstream signaling. Through these mechanisms, CD8A contributes to the activation, proliferation, and cytotoxic function of T cells.
The Recombinant CD8A antibody clone rC8/468 ensures precise and consistent recognition of CD8 alpha. Recombinant manufacturing reduces lot to lot variation and provides reliable performance across experiments. Clone rC8/468 has been applied in studies of thymic T cell development, peripheral immune responses, and tumor infiltrating lymphocytes. Its reproducibility makes it a dependable reagent for examining CD8 positive T cells in diverse research contexts.
Research using clone rC8/468 has expanded understanding of cytotoxic lymphocyte function in viral defense, vaccination responses, and cancer. CD8A detection is also valuable in immunopathology, where deficiencies or alterations in CD8 T cells contribute to disease progression. This antibody continues to aid investigations into how CD8 T cells shape host defense and how they may be harnessed in immunotherapy.
NSJ Bioreagents supplies this Recombinant CD8A antibody to support high quality studies of immune regulation. The protein is also referenced as CD8 alpha chain antibody, cytotoxic T cell marker antibody, T cell surface glycoprotein CD8A antibody, and cluster of differentiation 8A antibody, reflecting the varied terminology used by researchers.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the recombinant CD8A antibody to be titered up or down for optimal performance.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Human recombinant protein was used as the immunogen for this recombinant CD8A antibody.
Store the recombinant CD8A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.