- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD8A Antibody / Tumor Infiltrating Lymphocyte Marker Antibody [clone CDLA8a-2R] (V3684)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3684-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3684-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3684SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3684IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human. Other species not known. |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, k |
| Clone Name | CDLA8a-2R |
| Purity | Protein A affinity chromatography |
| UniProt | P01732 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT Prediluted IHC Only Format : incubate for 30 min at RT (1) |
| Limitations | This CD8A Antibody / Tumor Infiltrating Lymphocyte Marker Antibody is available for research use only. |
|
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CD8 alpha (CD8A) is a transmembrane glycoprotein expressed on cytotoxic T lymphocytes and functions as a co-receptor for T cell receptor signaling through interaction with MHC class I molecules. CD8A Antibody / Tumor Infiltrating Lymphocyte Marker Antibody is widely used to evaluate immune cell infiltration within tumors, where CD8-positive T cells serve as a key indicator of anti-tumor immune activity. CD8A antibody, also referred to as CD8 alpha antibody or CD8 antigen antibody, is one of the most commonly used markers for identifying tumor infiltrating lymphocytes in cancer research.
CD8A is localized to the plasma membrane of cytotoxic T cells, making it highly suitable for tissue-based detection of immune infiltrates by immunohistochemistry and multiplex imaging approaches. As a Tumor Infiltrating Lymphocyte Marker Antibody, CD8A is used not only to detect the presence of T cells, but also to assess their distribution within tumor nests, stromal compartments, and invasive margins. These spatial patterns are often biologically significant and can reflect differences in immune accessibility, tumor evasion, and microenvironmental regulation.
CD8-positive tumor infiltrating lymphocytes are central to cancer immunology, where their abundance and localization are frequently associated with prognosis and response to therapy. CD8A antibody is therefore widely used in studies examining immune hot versus immune cold tumors, evaluating immune exclusion, and monitoring changes in T cell infiltration following therapeutic intervention. This makes CD8A Antibody / Tumor Infiltrating Lymphocyte Marker Antibody a highly relevant tool for both discovery and translational oncology research.
In immunohistochemistry workflows, CD8A staining allows visualization of cytotoxic T lymphocytes within intact tissue architecture, providing context for how immune cells interact with tumor cells. In multiplex assays, CD8A is often combined with additional markers to define immune cell subsets and functional states within the tumor microenvironment. These approaches rely on clear and specific CD8A detection to accurately interpret immune infiltration patterns.
This antibody is part of a broader selection of immune cell marker antibodies designed to support studies of T cell biology, immune infiltration, and tumor immunology, including application-specific CD8A antibody reagents for IHC, FACS, WB, and IF.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD8A Antibody / Tumor Infiltrating Lymphocyte Marker Antibody to be titered up or down for optimal performance.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Recombinant full-length human CD8a protein was used as immunogen for this recombinant CD8 antibody.
Store the recombinant CD8 antibody (with azide) at 2-8oC. The azide-free format should be aliquoted and stored at -20oC or colder.
CD8A tumor infiltrating lymphocyte marker antibody, CD8 alpha TIL marker antibody, CD8A tumor immune infiltration antibody, CD8A cancer immune marker antibody, CD8A tumor microenvironment antibody
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