- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant CD7 Antibody Mouse Monoclonal [clone rCD7/6387] (V9149)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9149-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V9149-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V9149SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rCD7/6387 |
| Purity | Protein A/G affinity |
| UniProt | P09564 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant CD7 antibody is available for research use only. |
|
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CD7 antibody, also known as CD7 antigen antibody, recognizes Cluster of Differentiation 7, a type I transmembrane glycoprotein and member of the immunoglobulin superfamily expressed predominantly on thymocytes, mature T lymphocytes, and natural killer cells. CD7 is localized to the plasma membrane and functions as a co-stimulatory receptor involved in T cell activation, cytokine production, and immune signaling. Through its role in lymphocyte development and activation, CD7 contributes to immune surveillance and adaptive immune responses. CD7 antibody is therefore widely used in research focused on T cell lineage identification and immune regulation.
The CD7 gene is located on chromosome 17q25.2 and encodes a protein containing a single extracellular immunoglobulin-like domain, a transmembrane region, and a short cytoplasmic tail that participates in intracellular signaling cascades. CD7-mediated interactions influence pathways associated with lymphocyte proliferation and differentiation. CD7 antibody supports investigations into thymic maturation, peripheral T cell homeostasis, and the organization of lymphoid tissues.
CD7 antibody is particularly valuable in studies of hematologic malignancies. CD7 expression is frequently retained in T cell acute lymphoblastic leukemia and many peripheral T cell lymphomas, and aberrant expression may also be observed in subsets of acute myeloid leukemia. Evaluation of CD7 expression patterns can provide insight into lineage origin and disease characterization in lymphoproliferative disorders. As a result, CD7 antibody is commonly applied in research examining leukemic transformation and immune cell phenotyping.
Clone rCD7/6387 is a recombinant mouse monoclonal antibody developed to detect CD7 with high specificity and reproducibility. Recombinant expression ensures defined antibody sequence identity and consistent lot-to-lot performance. A recombinant CD7 Antibody mouse monoclonal format provides reliable detection of membrane-associated CD7 and supports consistent results across research applications.
Beyond oncology research, CD7 antibody is also relevant in studies of immune reconstitution, transplantation immunology, and autoimmune disease models where T cell subsets play central roles. By targeting a surface antigen expressed early during thymocyte development and maintained on mature T cells, clone rCD7/6387 serves as a dependable reagent for investigating T cell distribution, immune activation, and lymphoid tissue dynamics.
Optimal dilution of the recombinant CD7 antibody should be determined by the researcher.
A portion of amino acids 72-175 was used as the immunogen for the recombinant CD7 antibody.
Aliquot the recombinant CD7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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