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Home >> Antibodies >> Recombinant CD7 Antibody

Recombinant CD7 Antibody [clone CD7/8496R] (V4558)

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  Catalog No Formulation Size Price (USD)  
Image V4558-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V4558-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V4558SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
Microvalidated Recrabbitmono
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Immunohistochemistry analysis of CD7 antibody in human tonsil tissue. FFPE human tonsil tissue shows strong membranous HRP-DAB brown staining in lymphoid cells consistent with CD7-positive T lymphocytes, with surrounding non-lymphoid areas largely negative. Antigen retrieval was performed by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 20 minutes followed by cooling prior to incubation with recombinant CD7 antibody (clone CD7/8496R).
IHC staining of FFPE human tonsil tissue with recombinant CD7 antibody (clone CD7/8496R). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Rabbit
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name CD7/8496R
Purity Protein A/G affinity
UniProt P09564
Localization Cell Surface
Applications Western Blot : 1-2ug/ml
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Limitations This recombinant CD7 antibody is available for research use only.
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Description

CD7 antibody, also known as CD7 antigen antibody, recognizes Cluster of Differentiation 7, a transmembrane immunoglobulin superfamily member expressed predominantly on thymocytes, mature T lymphocytes, and natural killer cells. CD7 is a type I transmembrane glycoprotein localized to the plasma membrane and functions as a co-stimulatory receptor involved in T cell activation and immune signaling. It participates in early lymphoid development and contributes to T cell proliferation, cytokine production, and cellular interactions within lymphoid tissues. CD7 antibody is widely used in research examining T cell biology and lymphoid lineage commitment.

The CD7 gene is located on chromosome 17q25.2 and encodes a protein containing a single extracellular immunoglobulin-like domain, a transmembrane region, and a short cytoplasmic tail. Through its extracellular domain, CD7 mediates cell-cell interactions and modulates signaling cascades that influence immune responses. CD7 antibody supports studies focused on thymic maturation, peripheral T cell differentiation, and immune homeostasis. Because CD7 expression begins early during thymocyte development and persists on most mature T cells, it serves as a reliable lineage-associated marker in immunologic research.

CD7 antibody is particularly relevant in investigations of hematologic malignancies. CD7 is frequently expressed in T cell acute lymphoblastic leukemia and many peripheral T cell lymphomas, while altered or diminished expression may be observed in specific T cell neoplasms. Evaluation of CD7 expression patterns can provide insight into disease classification and cellular origin in lymphoproliferative disorders. A well-characterized CD7 antibody is therefore valuable for studying aberrant antigen expression and immune cell phenotyping in research settings.

Clone CD7/8496R is a recombinant rabbit monoclonal antibody developed to recognize CD7 with high specificity and reproducibility. Recombinant production in a defined expression system ensures consistent sequence identity and reliable performance across manufacturing lots. A CD7 antibody in recombinant rabbit monoclonal format offers the advantages of strong affinity, low background, and consistent reactivity, supporting its use in diverse laboratory applications designed to detect CD7 expression.

In addition to oncology-related research, CD7 antibody is useful in studies of immune reconstitution, transplantation immunology, and autoimmune disease models in which T cell subsets play central roles. By targeting a membrane-associated antigen that is broadly expressed in T lineage cells, clone CD7/8496R provides a dependable tool for investigating immune cell dynamics, lymphoid tissue organization, and signaling mechanisms associated with T cell activation.

Application Notes

Optimal dilution of the recombinant CD7 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 72-175) from the human protein was used as the immunogen for the recombinant CD7 antibody.

Storage

Aliquot the recombinant CD7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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