- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD5 Antibody / Immune Tolerance Regulator Antibody [clone rC5/6429] (V9322)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9322-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9322-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9322SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG2a, kappa |
| Clone Name | rC5/6429 |
| Purity | Protein A/G affinity |
| UniProt | P06127 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml Western Blot : 1-2ug/ml |
| Limitations | This CD5 Antibody / Immune Tolerance Regulator Antibody is available for research use only. |
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CD5 (CD5) is a transmembrane glycoprotein belonging to the scavenger receptor cysteine-rich (SRCR) superfamily, expressed on T lymphocytes and a subset of B cells. CD5 Antibody / Immune Tolerance Regulator Antibody is used to detect CD5 in the context of immune tolerance and signaling regulation, where it plays a critical role in maintaining immune homeostasis. CD5 antibody, also known as T cell surface glycoprotein CD5 antibody or LEU1 antibody, is widely used in studies of immune regulation, tolerance mechanisms, and lymphocyte biology.
CD5 functions as a negative regulator of antigen receptor signaling, dampening T cell receptor activation and preventing excessive or inappropriate immune responses. This regulatory activity is essential for maintaining tolerance to self-antigens and avoiding autoimmune activation. By setting signaling thresholds, CD5 helps ensure that lymphocytes respond selectively to true pathogenic stimuli while remaining unresponsive to self-derived signals. CD5 antibody is therefore an important tool for studying the molecular mechanisms that govern immune balance.
During thymic development, CD5 expression levels are closely linked to T cell selection processes, where signaling strength determines whether developing thymocytes undergo positive selection, negative selection, or deletion. In mature T cells, CD5 continues to influence signaling sensitivity and contributes to the maintenance of peripheral tolerance. Its expression on select B cell subsets further supports its role in broader immune regulatory networks. CD5 antibody enables investigation of these tolerance-related processes across different stages of lymphocyte development and function.
In disease settings, disruptions in CD5-mediated signaling can contribute to autoimmune disorders, chronic inflammatory conditions, and lymphoid malignancies. Reduced or altered CD5 function may lead to increased immune reactivity, while aberrant expression patterns may be associated with disease progression. CD5 antibody supports research into these conditions by enabling detection of CD5 in systems examining immune tolerance breakdown and dysregulated signaling.
Because immune tolerance is a fundamental aspect of immune system stability, CD5 antibody is frequently used in studies of regulatory T cell function, signaling threshold modulation, and immune checkpoint biology. Its detection provides insight into how immune cells maintain balance and how this balance is altered in disease. CD5 antibody for tolerance-focused research is therefore particularly valuable in studies of immune homeostasis and therapeutic intervention strategies.
This antibody is suitable for detecting CD5 in research applications focused on immune tolerance and regulatory signaling. Its ability to identify CD5 across lymphocyte populations supports studies of immune homeostasis, tolerance mechanisms, and disease-associated changes in immune regulation.
Because CD5 is a key regulator of immune tolerance, CD5 antibody is widely used in studies of lymphocyte signaling balance, immune system stability, and the prevention of aberrant immune activation.
A full range of CD5 antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD5 Antibody collection page.
Optimal dilution of the CD5 Antibody / Immune Tolerance Regulator Antibody should be determined by the researcher.
Recombinant full-length protein corresponding to human CD5 was used as the immunogen for the recombinant CD5 antibody.
Aliquot the recombinant CD5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
CD5 immune tolerance antibody, CD5 tolerance regulator antibody, CD5 immune modulation antibody, CD5 signaling threshold antibody, CD5 immune homeostasis antibody
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