- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD5 Antibody / T Cell Development Marker Antibody [clone C5/6438R] (V9332)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9332-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9332-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9332SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | C5/6438R |
| Purity | Protein A/G affinity |
| UniProt | P06127 |
| Localization | Cell Surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CD5 Antibody / T Cell Development Marker Antibody is available for research use only. |
|
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CD5 (CD5) is a type I transmembrane glycoprotein of the scavenger receptor cysteine-rich (SRCR) superfamily, localized to the plasma membrane of thymocytes, mature T lymphocytes, and a subset of B cells. CD5 Antibody / T Cell Development Marker Antibody is used to detect CD5 in the context of lymphocyte development, where it plays a central role during thymocyte maturation and T cell lineage specification. CD5 antibody, also known as T cell surface glycoprotein CD5 antibody or LEU1 antibody, is widely used in studies of immune system development and differentiation.
CD5 expression is dynamically regulated during thymic development and is closely linked to signaling events that guide positive and negative selection of thymocytes. These processes determine whether developing T cells survive, differentiate, or undergo apoptosis, ultimately shaping the functional T cell repertoire. CD5 expression levels reflect the strength of T cell receptor signaling during these checkpoints, making CD5 antibody a valuable tool for studying thymocyte selection, signaling thresholds, and developmental progression within the thymus.
As thymocytes mature, CD5 expression becomes stabilized on peripheral T cells, where it continues to play a role in maintaining functional balance. Its developmental significance, however, lies in its ability to act as a surrogate marker for signaling intensity during early immune system formation. CD5 antibody for development-focused research enables detailed investigation of thymic architecture, including cortical and medullary regions, as well as the identification of distinct maturation stages within the T cell lineage.
CD5 is also expressed on specific B cell subsets, particularly those associated with innate-like immune responses, providing additional insight into lymphocyte differentiation pathways. Detection of CD5 across both T and B cell populations supports studies examining lineage relationships, developmental trajectories, and functional specialization within the immune system. This makes CD5 antibody a useful reagent for exploring the broader context of lymphocyte development beyond T cell biology alone.
In experimental models, CD5 antibody is frequently used to study immune system development in both physiological and disease settings, including models of immunodeficiency, thymic dysfunction, and developmental disorders. Its ability to reflect signaling strength during selection processes provides unique insight into how immune tolerance and specificity are established during early life stages.
This antibody is suitable for detecting CD5 in research applications focused on lymphocyte development and immune system maturation. Its ability to identify CD5 across developmental stages supports studies of thymocyte selection, lineage commitment, and immune system formation.
Because CD5 is closely linked to T cell development and maturation, CD5 antibody is widely used in studies of thymic biology, lymphocyte differentiation, and developmental immunology.
A full range of CD5 antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD5 Antibody collection page.
Optimal dilution of the CD5 Antibody / T Cell Development Marker Antibody should be determined by the researcher.
Recombinant full-length protein was used as the immunogen for the recombinant CD5 antibody.
Aliquot the recombinant CD5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
CD5 T cell development antibody, CD5 thymocyte marker antibody, CD5 lymphocyte maturation antibody, CD5 immune development antibody, CD5 thymus marker antibody
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