- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant CD4 antibody detects CD4, a surface glycoprotein encoded by the CD4 gene. CD4 is expressed on helper T cells, monocytes, macrophages, and dendritic cells, where it functions as a coreceptor for MHC class II-mediated antigen recognition. Because CD4 is critical for T-cell activation and is also the primary receptor for HIV, Recombinant CD4 antibody is indispensable in immunology, oncology, and infectious disease research.
CD4 is a type I transmembrane protein with four extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail containing signaling motifs. By associating with the tyrosine kinase Lck, CD4 stabilizes TCR-MHC interactions and enhances signaling. This costimulatory role supports proliferation, differentiation, and cytokine secretion. Its restricted expression on helper T-cell subsets makes CD4 an important marker for immune monitoring.
The Recombinant CD4 antibody clone CD4/3619R provides reliable and consistent detection. Recombinant technology ensures uniform performance across lots, minimizing variability. Clone CD4/3619R has been referenced in peer-reviewed publications exploring T-cell activation, tumor immunology, and HIV pathogenesis. Its versatility supports flow cytometry, immunohistochemistry, and in vitro functional assays where precise CD4 detection is needed.
Research using clone CD4/3619R has shown how CD4 defines helper T-cell subsets in both health and disease. In oncology, detection supports studies of tumor-infiltrating lymphocytes and anti-tumor immunity. In infectious disease, this antibody has clarified how CD4 serves as the entry receptor for HIV, providing insight into viral pathogenesis and vaccine development. Beyond pathology, CD4 detection is central to studies of immune regulation and tolerance.
NSJ Bioreagents supplies this Recombinant CD4 antibody to support immunology, oncology, and infectious disease research. Alternate designations include T-cell surface glycoprotein CD4 antibody, helper T-cell marker antibody, L3T4 antigen antibody, MHC class II coreceptor antibody, HIV receptor antibody, and CD4 molecule antibody.
Optimal dilution of the recombinant CD4 antibody should be determined by the researcher.
A portion of amino acids 216-396 from the human protein was used as the immunogen for the recombinant CD4 antibody.
Store the recombinant CD4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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