- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant CD3e Antibody / CD3 epsilon [clone C3e/3125R] (V7557)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V7557-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V7557-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V7557SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | C3e/3125R |
| Purity | Protein A affinity chromatography |
| UniProt | P07766 |
| Localization | Cell surface, cytoplasmic |
| Applications | ELISA (order BSA-free Format For Coating) : Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant CD3e antibody is available for research use only. |
|
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Recombinant CD3e antibody detects CD3 epsilon, a component of the CD3 complex encoded by the CD3E gene. CD3 epsilon is an integral part of the T-cell receptor complex, which is essential for antigen recognition and T-cell activation. Because CD3 is expressed on nearly all mature T cells, Recombinant CD3e antibody is an indispensable tool in immunology, oncology, and diagnostic research.
The CD3 complex includes CD3 epsilon, gamma, delta, and zeta chains, which associate with the T-cell receptor alpha and beta chains. CD3 epsilon contains immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic tail, which initiate signaling upon T-cell receptor engagement. These motifs recruit kinases such as Lck and Zap70, triggering cascades that regulate proliferation, differentiation, and cytokine production.
The Recombinant CD3e antibody clone C3e/3125R provides consistent and specific recognition. Recombinant production ensures reproducibility across batches, minimizing variability in long-term studies. Clone C3e/3125R has been referenced in peer-reviewed publications investigating T-cell signaling, thymocyte development, and immunotherapy. Its specificity makes it suitable for flow cytometry, immunohistochemistry, and functional assays of T-cell activation.
Research using clone C3e/3125R has demonstrated how CD3 epsilon expression is indispensable for T-cell development in the thymus and for peripheral immune responses. In oncology, CD3 detection helps characterize tumor-infiltrating lymphocytes and supports the development of bispecific antibodies and CAR T-cell therapies that rely on CD3 engagement. Beyond cancer, CD3 studies are central to understanding autoimmunity, infectious disease, and transplant rejection, where T-cell activity is a determining factor.
NSJ Bioreagents supplies this Recombinant CD3e antibody to support T-cell biology, immunotherapy, and diagnostic applications. Alternate names include CD3E antibody, T-cell surface glycoprotein CD3 epsilon chain antibody, T-cell receptor-associated protein epsilon antibody, T-cell receptor signaling component antibody, and thymocyte differentiation antigen antibody.
A full range of CD3e antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD3e Antibody collection page.
Optimal dilution of the recombinant CD3e antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 23-119) was used as the immunogen for the recombinant CD3e antibody.
Store the recombinant CD3e antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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