- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD38 Antibody / Activated Lymphocyte Marker Antibody [clone CD38/6448R] (V9180)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9180-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9180-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9180SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | CD38/6448R |
| Purity | Protein A/G affinity |
| UniProt | P28907 |
| Localization | Cell Surface, Cytoplasm |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CD38 Antibody / Activated Lymphocyte Marker Antibody is available for research use only. |
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CD38 (CD38) is a multifunctional type II transmembrane glycoprotein and ectoenzyme that regulates NAD metabolism and calcium signaling, playing a central role in immune activation and intracellular signaling pathways. It is expressed across multiple immune cell types, including activated T cells, B cells, natural killer cells, and plasma cells, where its expression level is closely linked to cellular activation status and functional state. This dynamic regulation makes CD38 a valuable marker for identifying activated lymphocyte populations in diverse biological systems.
CD38 Antibody / Activated Lymphocyte Marker Antibody is uniquely positioned for detection of activation-dependent CD38 expression, enabling analysis of immune cell activation states within complex cellular and tissue environments. CD38 antibody, also referred to as cyclic ADP-ribose hydrolase antibody or ADPRC1 antibody, is widely used to characterize functional immune responses and to distinguish activated cells from naïve or resting counterparts.
In lymphocyte populations, CD38 expression is upregulated following activation, resulting in increased surface density that can be readily detected. Activated T cells and B cells typically exhibit intermediate to high CD38 expression, forming distinct populations relative to CD38-low or negative resting cells. This expression gradient allows CD38 to serve as both a qualitative and quantitative marker of immune activation, supporting detailed analysis of immune response dynamics.
CD38 is frequently used in studies of immune stimulation, inflammation, and immune-mediated disease, where identification of activated lymphocytes provides insight into ongoing biological processes. Its expression can reflect responses to antigen exposure, cytokine signaling, or disease-associated activation, making it a useful indicator of immune system engagement.
In addition to its role as a surface marker, CD38 contributes directly to signaling pathways that regulate immune cell activation. Through its enzymatic activity, CD38 generates cyclic ADP-ribose, which participates in calcium mobilization and intracellular signaling cascades. These processes are closely linked to lymphocyte activation, proliferation, and effector function, reinforcing the association between CD38 expression and immune activity.
CD38 is often analyzed in conjunction with other activation and lineage markers to refine identification of specific immune cell subsets. Its integration into multiparametric analysis supports detailed characterization of immune populations and their functional states within both normal and disease contexts.
The ability to detect CD38 expression as a marker of activation makes it particularly valuable in studies examining immune response kinetics, cellular differentiation, and functional immune status. Its dynamic expression profile allows researchers to track changes in immune cell populations over time or in response to experimental conditions.
CD38 Antibody CD38/6448R for activated lymphocyte detection therefore provides a powerful tool for identifying and characterizing immune activation states, supporting research into immune regulation, inflammatory processes, and disease-associated immune responses.
This antibody is part of our CD38 antibody collection, which includes application-specific formats for immunohistochemistry, flow cytometry, western blot, and immunofluorescence research.
Optimal dilution of the CD38 Antibody / Activated Lymphocyte Marker Antibody should be determined by the researcher.
A portion of amino acids 200-300 of human CD38 protein was used as the immunogen for the recombinant CD38 antibody.
Aliquot the recombinant CD38 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
CD38 activated lymphocyte antibody, CD38 immune activation marker antibody, CD38 T cell activation antibody, CD38 B cell activation antibody
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