- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant CD23 Antibody FCER2/4395R [clone FCER2/4395R] (V8470)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8470-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8470-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
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V8470SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | FCER2/4395R |
| Purity | Protein A affinity chromatography |
| UniProt | P06734 |
| Localization | Cell surface |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant CD23 antibody is available for research use only. |
|
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Recombinant CD23 Antibody FCER2/4395R recognizes CD23, also known as Low affinity immunoglobulin epsilon Fc receptor or Fc epsilon receptor II, encoded by the FCER2 gene on chromosome 19p13.3. CD23 is a type II transmembrane glycoprotein and a member of the C-type lectin family, primarily expressed on mature B lymphocytes and certain activated immune cells. As the low affinity receptor for IgE, CD23 plays a central role in regulating IgE mediated immune responses and B cell function.
Structurally, CD23 contains a short N-terminal cytoplasmic domain, a single transmembrane region, and a large extracellular C-type lectin-like domain responsible for IgE binding. In addition to membrane bound CD23, a soluble form can be generated by proteolytic cleavage, allowing it to function in a cytokine-like manner. Through its interaction with IgE and CD21, CD23 participates in antigen presentation, regulation of IgE synthesis, and modulation of B cell activation and differentiation. CD23 is predominantly localized to the cell membrane, with possible cytoplasmic staining depending on processing and activation state.
In normal tissues, CD23 expression is most prominent on follicular B cells within lymphoid tissues such as tonsil, lymph node, and spleen. It is commonly detected in germinal centers and mantle zones, reflecting its role in humoral immune regulation. Because of this restricted expression pattern, CD23 antibody is widely used in research settings to study B cell biology and immune activation. CD23 detection is also valuable in the characterization of certain B cell lymphoproliferative disorders, where its expression profile contributes to immunophenotypic assessment.
Altered CD23 expression has been associated with allergic diseases, asthma, and specific B cell malignancies, including chronic lymphocytic leukemia. By targeting CD23 with high specificity, Recombinant CD23 Antibody FCER2/4395R provides a consistent reagent for detecting CD23 expression in relevant research applications focused on immunology and lymphoid tissue biology.
Optimal dilution of the recombinant CD23 antibody should be determined by the researcher.
A portion of amino acids 221-321 from the human protein was used as the immunogen for the recombinant CD23 antibody FCER2/4395R.
Store the recombinant CD23 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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