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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2) or CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.
Optimal dilution of the recombinant CD21 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 900-1033) from the human protein was used as the immunogen for the recombinant CD21 antibody.
Aliquot the recombinant CD21 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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