- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD209 Antibody / C-Type Lectin Receptor Antibody [clone rC209/1781] (V7840)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V7840-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V7840-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V7840SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rC209/1781 |
| Purity | Protein G affinity chromatography |
| UniProt | Q9NNX6 |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CD209 Antibody / C-Type Lectin Receptor Antibody is available for research use only. |
|
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CD209 Antibody / C-Type Lectin Receptor Antibody detects CD209, a type II transmembrane glycoprotein also widely known as DC-SIGN. CD209 is expressed by dendritic cells and selected macrophage populations and functions as a C-type lectin receptor involved in carbohydrate recognition, cell adhesion and immune responses. The extracellular region contains a carbohydrate-recognition domain that binds specific glycan structures on both endogenous cells and microorganisms, providing a molecular link between immune-cell interactions and pathogen recognition.
DC-SIGN contains an N-terminal cytoplasmic region, a transmembrane domain, an extracellular neck region composed of tandem repeats and a C-terminal C-type lectin carbohydrate-recognition domain. The neck region contributes to receptor oligomerization, allowing CD209 to engage multivalent carbohydrate ligands with increased avidity. This structural organization supports the receptor's dual functions in recognition of glycosylated ligands and adhesion between immune cells.
CD209 was characterized in part through its interaction with ICAM-3 and contributes to contacts between dendritic cells and T cells. DC-SIGN can also interact with ICAM-2 and is studied in dendritic cell trafficking and immune-cell adhesion. These interactions are relevant to the ability of dendritic cells to capture antigens, migrate between tissues and lymphoid compartments, and communicate with cells of the adaptive immune system.
The C-type lectin receptor activity of DC-SIGN also enables recognition of carbohydrate structures displayed by diverse microorganisms. CD209 is therefore extensively investigated in host-pathogen interactions and innate immune recognition. Depending on the microorganism and biological context, DC-SIGN-mediated binding can contribute to pathogen capture and internalization, while certain pathogens can exploit the receptor during infection. These properties make CD209 relevant to research spanning dendritic cell biology, macrophage function, microbiology and immune regulation.
Clone rC209/1781 is a recombinant mouse monoclonal antibody generated using a recombinant partial human protein as immunogen. It has been evaluated by immunohistochemistry in FFPE human colon carcinoma tissue. Recombinant production provides a defined antibody sequence and supports consistent performance across manufacturing lots. NSJ Bioreagents supplies antibodies for immunology, dendritic cell and host-pathogen interaction research. A CD209 Antibody can be used to investigate C-type lectin receptor expression, DC-SIGN biology, pathogen recognition and immune-cell adhesion.
For broader research on CD209 expression, dendritic cell biology and pathogen recognition, see our DC-SIGN Antibody / Dendritic Cell Marker Antibody page.
Optimal dilution of the CD209 Antibody / C-Type Lectin Receptor Antibody should be determined by the researcher.
A human recombinant partial protein was used as the immunogen for this recombinant CD209 antibody.
Store the recombinant CD209 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD209 antibody, C-Type Lectin Receptor antibody, DC-SIGN antibody, Dendritic Cell-Specific ICAM-3-Grabbing Non-Integrin antibody, CLEC4L antibody
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