- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
CD20 Antibody Rabbit Monoclonal [clone MS4A1/7015R] (V9519)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9519-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V9519-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9519SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | MS4A1/7015R |
| Purity | Protein A affinity |
| UniProt | P11836 |
| Localization | Cell surface |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This CD20 antibody is available for research use only. |
|
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CD20 antibody recognizes CD20, also known as Membrane spanning 4-domains subfamily A member 1, a B-cell specific transmembrane phosphoprotein encoded by the MS4A1 gene. CD20 is localized to the plasma membrane of B lymphocytes, where it regulates B-cell activation, proliferation, and calcium flux. CD20 Antibody Rabbit Monoclonal is developed to support research in B-cell immunology, lymphoma biology, and CD20-targeted therapeutic studies.
The MS4A1 gene is located on chromosome 11q12.2 and encodes a protein characterized by four transmembrane domains with short cytoplasmic N- and C-terminal tails. CD20 expression begins at the late pre-B-cell stage and continues through mature B cells but is absent on hematopoietic stem cells and terminally differentiated plasma cells. This lineage-restricted expression makes CD20 one of the most widely used markers for identifying B-cell populations in lymphoid tissues such as tonsil, spleen, and lymph node.
Functionally, CD20 associates with the B-cell receptor signaling complex and contributes to calcium influx following antigen engagement. Although CD20 does not bind a defined soluble ligand, it participates in membrane microdomains that regulate signal transduction and B-cell activation. Aberrant CD20 expression is observed in B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, and other lymphoproliferative disorders. CD20 Antibody Rabbit Monoclonal enables detailed evaluation of CD20 distribution and expression levels in both normal and malignant B-cell populations.
CD20 is also a clinically significant therapeutic target. Anti-CD20 monoclonal antibodies are widely used to deplete B cells through complement activation, antibody-dependent cellular cytotoxicity, and apoptosis induction. Understanding CD20 density, membrane organization, and antigen modulation remains important for investigating treatment response and resistance. Clone MS4A1/7015R is engineered as a rabbit monoclonal antibody to provide consistent specificity and reproducibility in CD20 detection.
By targeting a well-established B-cell surface antigen, CD20 Antibody Rabbit Monoclonal supports studies in lymphoma classification, immune regulation, and translational research focused on CD20-directed therapies.
Optimal dilution of the CD20 antibody should be determined by the researcher.
A portion of amino acids 97-297 was used as the immunogen for the CD20 antibody.
Aliquot the CD20 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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