CD1A Antibody / Dendritic Cell Differentiation Marker Antibody [clone rC1A/711] (V3541)

Description

CD1 molecule alpha 1 (CD1A) is a membrane glycoprotein encoded by the CD1A gene that is widely used as a marker of dendritic cell differentiation and immune lineage development. CD1A antibody, also referred to as CD1a antibody or T-cell surface glycoprotein CD1a antibody, enables detection of CD1A expression in studies examining the development and maturation of antigen-presenting cells. CD1A Antibody is particularly useful for identifying dendritic cell subsets and tracking their differentiation from precursor populations within the immune system.

CD1a expression is closely associated with immature and developing dendritic cells, including Langerhans cells and thymocyte-related immune populations. During hematopoietic differentiation, CD1A is upregulated as progenitor cells acquire antigen-presenting capabilities, marking a transition toward functional dendritic cell identity. This makes CD1A a valuable marker for distinguishing early-stage dendritic cells from other leukocyte populations and for studying lineage commitment within the immune system.

In tissue and cellular models, CD1a-positive cells can be used to identify developing antigen-presenting cells and to evaluate changes in differentiation status under different biological conditions. This is particularly relevant in studies of immune development, where shifts in CD1A expression reflect progression along dendritic cell maturation pathways. Detection of CD1a therefore supports analysis of how precursor cells evolve into specialized immune cells capable of antigen presentation.

Alterations in dendritic cell differentiation are associated with immune dysregulation, inflammatory disorders, and changes in immune competence. CD1A expression can be used to monitor these alterations, providing insight into how immune cell populations respond to environmental signals, cytokine exposure, or pathological conditions. A CD1a antibody enables researchers to track these changes and to characterize the composition of developing immune cell populations.

CD1A Antibody is therefore well suited for studies focused on dendritic cell differentiation and immune lineage analysis. Its use supports identification of developing antigen-presenting cells and enables investigation of cellular pathways that regulate immune system development, maturation, and functional specialization.

A full range of CD1A antibody reagents for immunohistochemistry, western blot, and flow cytometry is available on our CD1A Antibody collection page.

Application Notes

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD1A Antibody / Dendritic Cell Differentiation Marker Antibody to be titered up or down for optimal performance.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

Full length human CD1a protein was used as the immunogen for this CD1A Antibody / Dendritic Cell Differentiation Marker Antibody.

Storage

Store the recombinant CD1a antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Alternate Names

CD1a antibody, dendritic cell differentiation marker antibody, CD1A immune lineage antibody, Langerhans precursor marker antibody, T-cell surface glycoprotein CD1a antibody