- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Recombinant CD117 Antibody RM359 / Recombinant c-Kit Antibody recognizes KIT, a type III receptor tyrosine kinase also known as CD117, c-Kit and stem cell factor receptor. KIT is a transmembrane signaling protein that regulates cellular proliferation, survival, differentiation and migration. Binding of stem cell factor to the extracellular domain promotes receptor dimerization and activation of the intracellular kinase domain, initiating signaling events important to several specialized cell populations.
KIT contains five extracellular immunoglobulin-like domains, a single transmembrane region and an intracellular split tyrosine kinase domain. Ligand-induced activation results in receptor autophosphorylation and the recruitment of signaling proteins that connect KIT with pathways including PI3K/AKT and RAS/MAPK. These pathways help regulate cellular responses to stem cell factor and contribute to the maintenance and development of hematopoietic progenitors, mast cells, melanocytes and germ cells.
CD117 is widely used as a cellular marker, particularly in hematopoietic and tumor biology. KIT expression is associated with hematopoietic stem and progenitor populations as well as mast cells and several other cell types. Abnormal KIT expression or constitutive receptor activation can contribute to oncogenic signaling, and activating KIT mutations are particularly important in gastrointestinal stromal tumors and are also found in subsets of other malignancies.
Because KIT abundance and signaling status can vary with cell type, developmental state and disease context, detection of the receptor is useful for investigating both normal and abnormal cellular biology. Recombinant c-Kit Antibody reagents provide tools for studying expression of this receptor independently of its phosphorylation state.
NSJ Bioreagents offers clone RM359 as a recombinant rabbit monoclonal reagent for CD117 research. Recombinant production provides a defined antibody sequence and supports consistent recognition of the target across manufacturing lots. The Recombinant CD117 Antibody terminology emphasizes the widely used CD marker designation, while Recombinant c-Kit Antibody reflects another established name for the same receptor.
A Recombinant CD117 Antibody provides a defined monoclonal reagent for investigating KIT expression, while a Recombinant c-Kit Antibody supports research into stem cell factor receptor biology and KIT-associated signaling.
For a Protein Microarray Validated CD117 antibody with GIST IHC validation, see our CD117 Antibody C117/6347 / c-Kit Monoclonal Antibody.
The stated application concentrations are suggested starting points. Titration of the Recombinant CD117 Antibody RM359 / Recombinant c-Kit Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A peptide corresponding to the C-terminus of human CD117/c-Kit was used as the immunogen for the Recombinant CD117 Antibody RM359.
Store the Recombinant CD117 Antibody RM359 at -20oC.
c-Kit antibody, KIT antibody, Stem Cell Factor Receptor antibody, SCFR antibody, Mast/Stem Cell Growth Factor Receptor Kit antibody
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