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Home >> Antibodies >> Recombinant Caudal Type Homeobox 2 Antibody / CDX2

Recombinant Caudal Type Homeobox 2 Antibody / CDX2 [clone rCDX2/6921] (V9367)

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  Catalog No Formulation Size Price (USD)  
Image V9367-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9367-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9367SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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IHC staining of FFPE human colon carcinoma tissue with recombinant Caudal Type Homeobox 2 antibody (clone rCDX2/6921). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human colon carcinoma tissue with recombinant Caudal Type Homeobox 2 antibody (clone rCDX2/6921). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
IHC staining of FFPE human colon adenocarcinoma tissue with recombinant Caudal Type Homeobox 2 antibody (clone rCDX2/6921) at 2ug/ml in PBS for 30min RT. Negative control inset: PBS instead of primary antibody to control for secondary binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rCDX2/6921
Purity Protein A/G affinity
UniProt Q99626
Localization Nuclear
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant Caudal Type Homeobox 2 antibody is available for research use only.
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Description

The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

Application Notes

Optimal dilution of the recombinant Caudal Type Homeobox 2 antibody should be determined by the researcher.

Immunogen

A synthetic peptide from human CDX2 protein was used as the immunogen for the recombinant Caudal Type Homeobox 2 antibody.

Storage

Aliquot the recombinant Caudal Type Homeobox 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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