- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant ATRX Antibody / RAD54 [clone rATRX/3446] (V8409)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8409-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 539 | |
|
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V8409-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 249 | |
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V8409SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rATRX/3446 |
| Purity | Protein G affinity chromatography |
| UniProt | P46100 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant ATRX antibody is available for research use only. |
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Recombinant ATRX antibody detects ATRX, a chromatin remodeling protein encoded by the ATRX gene. ATRX belongs to the SWI/SNF family of helicase/ATPases and is involved in regulating gene expression, maintaining genomic stability, and shaping chromatin architecture. Mutations in ATRX are associated with developmental disorders and cancers, particularly gliomas and pancreatic neuroendocrine tumors. Because of its central role in chromatin regulation and disease, Recombinant ATRX antibody is widely applied in cancer biology, genetics, and epigenetics research.
ATRX contains an ATPase/helicase domain and an ADD domain that interacts with histone tails, linking chromatin remodeling to epigenetic signaling. It is essential for incorporation of histone variant H3.3 at telomeres and pericentric heterochromatin, maintaining structural integrity of repetitive regions. ATRX mutations can lead to loss of function, altered gene expression, and chromosomal instability, contributing to tumorigenesis and developmental syndromes such as ATR-X syndrome.
The Recombinant ATRX antibody clone rATRX/3446 provides reliable and consistent recognition. Recombinant technology ensures uniformity across production batches, an important factor in studies requiring reproducibility. Clone rATRX/3446 has been cited in peer-reviewed publications analyzing ATRX deficiency in tumors, telomere biology, and epigenetic regulation. Its applications include immunohistochemistry, immunoblotting, and chromatin studies.
Research using clone rATRX/3446 has demonstrated that ATRX loss correlates with the alternative lengthening of telomeres (ALT) phenotype in tumors, providing both diagnostic and prognostic insights. In developmental biology, ATRX disruption has been linked to intellectual disability and congenital anomalies. Studies employing this antibody have clarified how ATRX integrates chromatin remodeling with DNA repair and transcriptional regulation, advancing understanding of both normal physiology and pathology.
NSJ Bioreagents supplies this Recombinant ATRX antibody to support research in chromatin biology, epigenetics, and oncology. Alternate designations include alpha thalassemia mental retardation syndrome X-linked protein antibody, SWI/SNF family helicase ATRX antibody, ATR-X syndrome protein antibody, chromatin remodeler ATRX antibody, and histone variant H3.3 deposition factor antibody.
Optimal dilution of the recombinant ATRX antibody should be determined by the researcher.
Recombinant full-length human ATRX protein was used as the immunogen for the recombinant ATRX antibody.
Store the recombinant ATRX antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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