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Home >> Antibodies >> Recombinant Apolipoprotein J Antibody / Clusterin / CLU

Recombinant Apolipoprotein J Antibody / Clusterin / CLU [clone CLU/9192R] (V5461)

  Catalog No Formulation Size Price (USD)  
Image V5461-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 539
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V5461-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 249
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V5461SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 539
Microvalidated Recrabbitmono
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SDS-PAGE analysis of purified, BSA-free recombinant Apolipoprotein J antibody (clone CLU/9192R) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Rabbit Monoclonal
Isotype Rabbit IgG, kappa
Clone Name CLU/9192R
Purity Protein A/G affinity
UniProt P10909
Localization Cytoplasm
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This recombinant Apolipoprotein J antibody is available for research use only.
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Description

Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, alpha and beta, are associated through disulfide bonds. The Clusterin beta subunit (also called ApoJ-alpha) corresponds to residues 23-227. The alpha subunit (also called ApoJ-beta) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences b-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.

Application Notes

Optimal dilution of the recombinant Apolipoprotein J antibody should be determined by the researcher.

Immunogen

A recombinant fragment (within amino acids 410-440) of human Clusterin protein was used as the immunogen for the recombinant Apolipoprotein J antibody.

Storage

Aliquot the recombinant Apolipoprotein J antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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