- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Anaplastic Lymphoma Kinase Antibody / ALK Fusion Protein Antibody [clone rALK1/1504] (V8896)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8896-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V8896-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V8896SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rALK1/1504 |
| Purity | Protein A/G affinity |
| UniProt | Q9UM73 |
| Localization | Cytoplasm, Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Anaplastic Lymphoma Kinase Antibody / ALK Fusion Protein Antibody is available for research use only. |
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Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a receptor tyrosine kinase belonging to the insulin receptor superfamily that functions in neuronal development, cellular differentiation, and intracellular signaling regulation. Anaplastic Lymphoma Kinase Antibody / ALK Fusion Protein Antibody recognizes a transmembrane kinase receptor involved in signaling pathways associated with proliferation, survival, migration, and oncogenic transformation.
Anaplastic Lymphoma Kinase antibody, also referred to as ALK antibody and ALK fusion protein antibody in the literature, is widely used in cancer biology, molecular pathology, and precision oncology research applications. Recombinant mouse monoclonal clone rALK1/1504 supports investigation of ALK-associated oncogenic signaling pathways and tumor biology linked to chromosomal rearrangements and constitutively active kinase fusion proteins.
ALK is primarily localized to the plasma membrane where physiologic receptor activation contributes to nervous system-associated developmental signaling. In malignant cellular systems, however, chromosomal translocations and fusion events frequently generate constitutively active ALK fusion proteins capable of driving persistent downstream kinase signaling independent of normal ligand-mediated regulation. These oncogenic fusion-associated signaling pathways activate MAPK, PI3K-AKT, JAK-STAT, and additional proliferative cascades involved in malignant transformation.
Aberrant ALK activation is strongly associated with anaplastic large cell lymphoma, inflammatory myofibroblastic tumor, non-small cell lung carcinoma, neuroblastoma, and additional malignancies. In lung adenocarcinoma and lymphoma-associated pathology, ALK rearrangements define clinically significant molecular subsets linked to targeted kinase inhibitor sensitivity and precision oncology-associated therapeutic strategies.
Because ALK fusion-positive tumors frequently demonstrate dependence on constitutive kinase signaling, ALK-associated biomarker analysis has become highly important in translational oncology and molecular pathology research. Antibodies targeting Anaplastic Lymphoma Kinase are therefore widely used for characterization of oncogenic kinase signaling pathways and molecularly defined tumor populations.
Immunohistochemistry staining with ALK antibodies commonly demonstrates cytoplasmic, granular cytoplasmic, nuclear, or combined staining patterns depending on the specific fusion partner and tumor type examined. Strong ALK-associated staining in anaplastic large cell lymphoma and inflammatory myofibroblastic tumor aligns with the established role of ALK rearrangement-associated kinase activation in tumor-associated signaling biology.
Recombinant mouse monoclonal clone rALK1/1504 supports detection of ALK-associated protein expression in tumor-derived tissues and contributes to studies examining receptor tyrosine kinase activation, oncogenic fusion signaling, and targeted therapy-associated molecular pathways. The biologic importance of ALK in modern precision oncology further supports the value of Anaplastic Lymphoma Kinase antibodies in translational cancer research applications.
Together, the available immunohistochemistry data support the use of Anaplastic Lymphoma Kinase antibody clone rALK1/1504 for investigating ALK fusion-associated tumor biology, receptor tyrosine kinase signaling pathways, and oncogenic kinase activation mechanisms.
For additional ALK and oncogenic kinase research antibodies targeting fusion protein signaling, lung cancer biomarkers, and lymphoma-associated receptor tyrosine kinase pathways, explore the broader ALK Antibody page featuring recombinant rabbit monoclonal clone ALK1/6698R.
Optimal dilution of the Anaplastic Lymphoma Kinase Antibody / ALK Fusion Protein Antibody should be determined by the researcher.
A portion of amino acids 200-335 was used as the immunogen for the recombinant Anaplastic Lymphoma Kinase antibody.
Aliquot the Anaplastic Lymphoma Kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Anaplastic Lymphoma Kinase antibody, ALK antibody, CD246 antibody, ALK fusion protein antibody, oncogenic receptor tyrosine kinase antibody
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