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- Email: info@nsjbio.com
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The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [RefSeq]
Optimal dilution of the Rb1 antibody should be determined by the researcher.
A synthetic peptide specific to human Retinoblastoma / Rb was used as the immunogen for the Rb1 antibody.
Store the Rb1 antibody at -20oC.
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