- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
RAD54L2 Antibody / RAD54-like 2 (FY13030)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13030 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
RAD54L2 antibody detects DNA repair and recombination protein RAD54-like 2, a member of the SNF2 family of ATP-dependent chromatin remodelers involved in DNA repair, replication, and transcriptional regulation. The UniProt recommended name is DNA repair and recombination protein RAD54-like 2 (RAD54L2). Also known as ARIP4, this nuclear protein interacts with DNA and chromatin-associated factors to maintain genomic stability and regulate gene expression.
Functionally, RAD54L2 antibody identifies a 1330-amino-acid protein characterized by helicase-like ATPase domains and DNA-binding motifs. RAD54L2 participates in homologous recombination repair, facilitating the remodeling of chromatin to enable access of repair enzymes to damaged DNA. It also interacts with transcriptional co-regulators and nuclear hormone receptors, integrating DNA repair with transcriptional control. Through ATP hydrolysis, RAD54L2 alters nucleosome structure, promoting chromatin relaxation at sites of DNA damage.
The RAD54L2 gene is located on chromosome 3p21.31 and is widely expressed in proliferative tissues such as testis, ovary, and thymus. RAD54L2 shares structural homology with RAD54L, another member of the SWI2/SNF2 family involved in recombination repair, but exhibits broader functional diversity. RAD54L2 binds both double-stranded DNA and repair intermediates, enhancing strand invasion and exchange during homologous recombination. This role ensures error-free repair of double-strand breaks and prevents chromosomal rearrangements.
Beyond its DNA repair function, RAD54L2 acts as a transcriptional co-regulator by binding to androgen receptor (AR) and other nuclear receptors, modulating gene transcription in response to hormonal signaling. It is also implicated in chromatin condensation and mitotic progression. Dysregulation of RAD54L2 expression has been associated with genomic instability, altered hormone signaling, and cancer development. Elevated expression has been observed in certain tumors, where it may support DNA repair efficiency and resistance to genotoxic stress.
RAD54L2 antibody is widely used in DNA repair, chromatin remodeling, and cancer research. It is suitable for western blotting, immunoprecipitation, and immunofluorescence to detect RAD54L2 protein localization and expression. This antibody supports studies of homologous recombination, transcriptional regulation, and genome stability. In oncology, RAD54L2 detection aids in evaluating repair pathway activation and therapeutic response to DNA-damaging agents.
Structurally, RAD54L2 contains conserved ATP-binding Walker A and B motifs and DNA-binding helicase domains characteristic of SWI2/SNF2 family proteins. Its activity is regulated by post-translational modifications and interactions with transcriptional complexes. NSJ Bioreagents provides RAD54L2 antibody reagents validated for use in genomic stability, transcriptional regulation, and DNA repair research.
Optimal dilution of the RAD54L2 antibody should be determined by the researcher.
E.coli-derived human RAD54L2 recombinant protein (Position: R144-H1037) was used as the immunogen for the RAD54L2 antibody.
After reconstitution, the RAD54L2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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