RAD50 Antibody (RQ7032)

Description

RAD50 is a key component of the MRN complex, which also includes MRE11 and NBS1, and plays an essential role in the detection and repair of DNA double-strand breaks. Through its ATPase activity and structural domains, RAD50 helps tether DNA ends, enabling accurate processing and repair via homologous recombination or non-homologous end joining pathways. This function is critical for maintaining genomic stability and preventing accumulation of DNA damage.

RAD50 is expressed in a wide range of proliferating cells and is highly conserved across species, reflecting its fundamental role in DNA repair and cell cycle regulation. Beyond its function in DNA repair, RAD50 is also involved in telomere maintenance and meiotic recombination, making it an important protein for studies in genomic maintenance and cellular stress responses.

The RAD50 antibody is a highly specific reagent for detecting endogenous RAD50 in applications such as western blot, immunohistochemistry, and immunofluorescence. Researchers use the RAD50 antibody from NSJ Bioreagents to analyze protein expression patterns, study DNA damage response pathways, and investigate the molecular mechanisms of genomic repair. With proven reliability and consistent performance, the RAD50 antibody supports research into genome stability, DNA repair processes, and cellular defense mechanisms against genotoxic stress.

Application Notes

Optimal dilution of the RAD50 antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids N1224-H1312) was used as the immunogen for the RAD50 antibody.

Storage

After reconstitution, the RAD50 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.