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Home >> Antibodies >> RAC1 Antibody

RAC1 Antibody [clone 1301CT276.121.104] (F52547)

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  Catalog No Formulation Size Price (USD)  
Image F52547-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F52547-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot analysis of lysate from (1) human A431, (2) mouse NIH3T3, (3) rat C6 cell line using RAC1 antibody at 1:1000.
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Western blot analysis of lysate from (1) human A431, (2) mouse NIH3T3, (3) rat C6 cell line using RAC1 antibody at 1:1000.
Immunohistochemical analysis of paraffin-embedded human skin section using RAC1 antibody at 1:25 dilution.
Immunohistochemical analysis of paraffin-embedded human stomach section using RAC1 antibody at 1:25 dilution.
Flow cytometric analysis of U-87 MG cells using RAC1 antibody (green) and an isotype control of mouse IgG2b (blue); Ab was diluted at 1:100 dilution.
Availability 1-3 business days
Species Reactivity Human, Rat
Predicted Reactivity Bovine, Mouse
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Clone Name 1301CT276.121.104
Purity Purified
UniProt P63000
Applications Flow Cytometry : 1:100
IHC (Paraffin) : 1:25
Western blot : 1:1000
Limitations This RAC1 antibody is available for research use only.
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Description

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.

Application Notes

Titration of the RAC1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This RAC1 antibody was produced from a mouse immunized with a KLH conjugated synthetic peptide from the human protein.

Storage

Aliquot the RAC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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