PUS7 Antibody / Pseudouridylate synthase 7 (RQ8434)

Description

PUS7 (Pseudouridylate synthase 7) is an enzyme that catalyzes the isomerization of uridine to pseudouridine in various classes of RNA, including tRNA and mRNA. This post-transcriptional modification enhances RNA stability, influences secondary structure, and can modulate translation efficiency. PUS7 activity is part of the broader RNA modification landscape that fine-tunes gene expression and cellular responses to environmental cues.

PUS7 is conserved across eukaryotes and is expressed in multiple tissues, with notable roles in developmental regulation and stress adaptation. Its function in mRNA pseudouridylation has been linked to regulation of gene networks involved in cell differentiation, proliferation, and response to metabolic changes. Because of its impact on RNA biology, PUS7 is of interest in studies exploring epitranscriptomic mechanisms and RNA-based regulation.

The PUS7 antibody is a valuable reagent for detecting endogenous PUS7 in applications such as western blot, immunohistochemistry, and immunofluorescence. Researchers use the PUS7 antibody from NSJ Bioreagents to evaluate expression patterns, study subcellular localization, and investigate the enzyme’s role in RNA modification pathways. With high specificity and reproducible performance, the PUS7 antibody supports detailed research in RNA biology, molecular genetics, and post-transcriptional regulation.

Application Notes

Optimal dilution of the PUS7 antibody should be determined by the researcher.

Immunogen

An E.coli-derived human recombinant protein (D294-H541) was used as the immunogen for the PUS7 antibody.

Storage

After reconstitution, the PUS7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.