- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PTPRU Antibody / Protein Tyrosine Phosphatase Receptor Type U [clone PTPRU/7616] (V4686)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
V4686-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 519 | |
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V4686-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 229 | |
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V4686SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 519 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2, kappa |
| Clone Name | PTPRU/7616 |
| Purity | Protein A/G affinity |
| UniProt | Q92729 |
| Localization | Cell junction, Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This PTPRU antibody is available for research use only. |
|
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Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPa, PTPb, PTPg, PTPd, PTPe, PTPz, PTPk, PTPm and PTPy. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTPy, also known as PTPRU, FMI, PCP-2, PTP-J, PTPRO, PTP-PI, PTPPSI or GLEPP1, is a receptor-type PTP containing a transmembrane region, two intracellular tandem catalytic domains, and an extracellular region with Ig-like and fibronectin type III-like repeats and a MAM (meprin-A5 antigen-PTPm) domain. PTPy localizes to adheren junctions and is capable of binding and dephosphorylating b-catenin thereby functioning as a negative regulator of b-catenin signaling. In addition, PTPy may function as a tumor suppressor, as its expression is silenced in a variety of tumors via methylation of its promoter.
Optimal dilution of the PTPRU antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the PTPRU antibody.
Aliquot the PTPRU antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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