- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Proteasome Alpha 4 Antibody / PSMA4 Polyclonal Antibody (R35848)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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R35848-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 5685 |
| Localization | Cytoplasmic, nuclear |
| Applications | Western blot: 1-3ug/ml ELISA (peptide) LOD: 1:4000 |
| Limitations | This Proteasome Alpha 4 Antibody / PSMA4 Polyclonal Antibody is available for research use only. |
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Proteasome Alpha 4 Antibody / PSMA4 Polyclonal Antibody recognizes PSMA4, a noncatalytic alpha subunit of the 20S proteasome core particle. Also known as proteasome subunit alpha type-4, macropain subunit C9, and proteasome component C9, PSMA4 contributes to the structural organization of the proteasome, a protein complex responsible for intracellular protein degradation. The proteasome system maintains protein homeostasis by removing proteins that are damaged, misfolded, or no longer required for normal cellular functions.
The 20S proteasome core consists of four stacked rings arranged around a central proteolytic chamber. Each outer ring contains seven different alpha subunits, including PSMA4, while the two inner rings contain beta subunits responsible for peptide bond cleavage. The alpha rings provide structural support and help regulate substrate entry into the catalytic chamber. Their organization is important for maintaining the integrity of the assembled complex and coordinating interactions with regulatory particles that influence proteasome activity.
When the 20S core associates with 19S regulatory particles, it forms the 26S proteasome, which participates in the ubiquitin-proteasome system. Proteins targeted for degradation are frequently modified with ubiquitin chains that are recognized by the regulatory machinery. These substrates are subsequently unfolded and directed into the proteolytic chamber for degradation. This process helps regulate the turnover of proteins involved in cell cycle control, transcriptional regulation, cellular signaling, and stress responses. Proteasome function also supports the removal of abnormal proteins that could otherwise accumulate and interfere with cellular activity.
PSMA4 is broadly expressed and contributes to proteasome activity in both nuclear and cytoplasmic compartments. Changes in proteasome composition or function can influence cellular responses to proteotoxic stress and alter the stability of regulatory proteins. Studying this subunit can help clarify the relationship between proteasome structure, protein turnover, and cellular adaptation to changing conditions. NSJ Bioreagents offers this Proteasome Alpha 4 Antibody for research examining PSMA4 and the molecular machinery responsible for maintaining intracellular protein balance.
For additional research options, explore our PSMA4 Antibody, which has been evaluated by Western blot using human and rodent samples.
Optimal dilution of the Proteasome Alpha 4 Antibody / PSMA4 Polyclonal Antibody should be determined by the researcher.
Amino acids SDANVLTNELR were used as the immunogen for this Proteasome Alpha 4 Antibody.
Aliquot and store the Proteasome Alpha 4 Antibody at -20oC.
Proteasome subunit alpha type-4 antibody, Macropain subunit C9 antibody, Proteasome component C9 antibody, 20S proteasome alpha-4 subunit antibody
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