- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
PRTN3 Antibody / Proteinase 3 / Myeloblastin (RQ8145)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8145 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P24158 |
| Localization | Cell membrane, cytoplasm, secreted |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml Immunofluorescence : 5ug/ml |
| Limitations | This PRTN3 antibody is available for research use only. |
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PRTN3 antibody targets Proteinase 3, also known as Myeloblastin, encoded by the PRTN3 gene. Proteinase 3 is a serine protease belonging to the chymotrypsin-like elastase family and is predominantly expressed in neutrophils and other myeloid lineage cells. It is synthesized as an inactive zymogen and stored in azurophilic granules, where it contributes to innate immune defense mechanisms following activation and release.
Functionally, Proteinase 3 participates in proteolytic processing of extracellular matrix components and microbial proteins during inflammatory responses. It is also involved in the regulation of cytokine activity and modulation of immune signaling at sites of infection or tissue injury. Through these protease-dependent activities, Proteinase 3 supports host defense but can also contribute to tissue damage when proteolytic activity is excessive or dysregulated. A PRTN3 antibody supports studies focused on neutrophil biology, inflammatory signaling, and protease-mediated immune responses.
PRTN3 expression is largely restricted to cells of myeloid origin, including neutrophils, monocytes, and myeloblasts. Subcellular localization is primarily within cytoplasmic granules, although Proteinase 3 can be detected at the cell surface or in extracellular spaces following degranulation or secretion. Localization and availability are therefore highly dependent on cellular activation state and inflammatory context.
From a disease relevance perspective, Proteinase 3 is a well-characterized autoantigen in anti-neutrophil cytoplasmic antibody-associated vasculitis, particularly granulomatosis with polyangiitis. Aberrant regulation of Proteinase 3 activity has also been investigated in chronic inflammatory conditions and tissue remodeling disorders. At the molecular level, Proteinase 3 contains a conserved serine protease catalytic triad responsible for its enzymatic activity. PRTN3 antibody reagents support research applications examining neutrophil protease function, inflammatory disease mechanisms, and immune-mediated tissue injury, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the PRTN3 antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids A23-D241) was used as the immunogen for the PRTN3 antibody.
After reconstitution, the PRTN3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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