- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Protein-glutamine Gamma-glutamyltransferase 2 Antibody / Transglutaminase 2 recognizes Protein-glutamine gamma-glutamyltransferase 2, more commonly known as Transglutaminase 2 (TGM2), a multifunctional enzyme that catalyzes calcium-dependent protein crosslinking while also functioning as a signaling and structural protein. Although widely referred to as Transglutaminase 2 in the scientific literature, the Protein-glutamine gamma-glutamyltransferase 2 designation reflects its enzymatic role in forming covalent crosslinks between glutamine and lysine residues within target proteins. The protein is broadly expressed in epithelial, endothelial, stromal, and immune cells and is present in both intracellular compartments and the extracellular matrix. A Protein-glutamine Gamma-glutamyltransferase 2 Antibody / Transglutaminase 2 provides an effective tool for examining protein expression, localization, and regulation across a wide range of biological systems.
Protein-glutamine gamma-glutamyltransferase 2 contributes to extracellular matrix stabilization, cell adhesion, migration, differentiation, apoptosis, and wound repair through both enzymatic and non-enzymatic mechanisms. In addition to its transamidase activity, the protein functions as a GTP-binding molecule and signaling scaffold that interacts with fibronectin, integrins, growth factor receptors, and cytoskeletal proteins. These diverse activities allow Transglutaminase 2 to coordinate cellular responses to tissue injury, mechanical stress, inflammation, and extracellular matrix remodeling while maintaining tissue integrity under physiological conditions.
Altered expression or activity of Protein-glutamine gamma-glutamyltransferase 2 has been associated with numerous pathological conditions, including fibrosis, cancer, autoimmune disease, cardiovascular disorders, and neurodegeneration. Increased Transglutaminase 2 activity promotes extracellular matrix accumulation and fibrotic remodeling, while elevated expression in many tumors has been linked to epithelial-mesenchymal transition, tumor invasion, metastasis, and resistance to therapy. The protein is also recognized as the principal autoantigen in celiac disease, making it an important target for studies of immune-mediated intestinal pathology. A Protein-glutamine Gamma-glutamyltransferase 2 Antibody / Transglutaminase 2 supports investigations into these diverse disease mechanisms while enabling reliable detection of this multifunctional enzyme.
Protein-glutamine gamma-glutamyltransferase 2 antibodies are suitable for applications including Western blotting, immunohistochemistry, immunofluorescence, flow cytometry, immunoprecipitation, and related protein detection methods when validated for the specific application. Because Transglutaminase 2 functions in multiple cellular compartments and exists in distinct conformational states, appropriate controls and application-specific optimization are recommended. NSJ Bioreagents provides carefully validated antibodies to support investigations of extracellular matrix biology, fibrosis, autoimmune disease, cancer progression, and tissue remodeling. A Protein-glutamine Gamma-glutamyltransferase 2 Antibody / Transglutaminase 2 is a valuable research reagent for detecting Transglutaminase 2 and advancing studies of protein crosslinking, cell adhesion, extracellular matrix organization, and disease-associated tissue remodeling.
Visit our TGM2 Antibody / Transglutaminase 2 Antibody page to explore additional validated antibodies and research tools for investigating TGM2 expression, extracellular matrix remodeling, cell adhesion, fibrosis, and cancer progression.
The stated application concentrations are suggested starting points. Titration of the Protein-glutamine gamma-glutamyltransferase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 429-458 from the human protein was used as the immunogen for the Protein-glutamine gamma-glutamyltransferase 2 antibody.
Aliquot the Protein-glutamine gamma-glutamyltransferase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Protein-glutamine Gamma-glutamyltransferase 2 antibody, Transglutaminase 2 antibody, TGM2 antibody, TG2 antibody, Tissue Transglutaminase antibody, Transglutaminase C antibody
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