- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Prostein Antibody / Secretory Epithelial Cell Function Antibody [clone SLC45A3/7650] (V4784)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4784-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4784-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4784SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | SLC45A3/7650 |
| Purity | Protein A/G affinity |
| UniProt | Q96JT2 |
| Localization | Membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Prostein antibody is available for research use only. |
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Solute carrier family 45 member 3 (SLC45A3), commonly known as Prostein, is a prostate-specific protein encoded by the SLC45A3 gene and localized to the Golgi apparatus of secretory epithelial cells. Prostein Antibody is used to detect SLC45A3 in the context of secretory epithelial cell function, providing insight into protein processing, trafficking, and secretion within prostate tissue.
Prostein antibody, also referred to as SLC45A3 antibody or prostate-specific androgen-regulated protein antibody, is highly expressed in luminal epithelial cells of the prostate, which are specialized for secretory activity. These cells are responsible for producing and releasing proteins that contribute to glandular function, and SLC45A3 expression reflects the active secretory state of these epithelial populations.
The Golgi apparatus plays a central role in the secretory pathway, serving as the site of protein modification, sorting, and packaging prior to transport to their final destinations. Localization of SLC45A3 to this compartment positions it within the core machinery responsible for maintaining efficient secretion. The characteristic perinuclear staining pattern observed with Prostein detection reflects this Golgi-centered functional role.
Secretory epithelial cells depend on tightly regulated intracellular trafficking to maintain polarity and ensure directional protein release. SLC45A3 is thought to contribute to these processes by supporting Golgi-associated transport and vesicular trafficking pathways. Its expression therefore provides insight into the functional state of epithelial cells, particularly in tissues with high secretory demand such as the prostate.
In disease contexts, including prostate cancer, alterations in secretory pathway function can influence cellular organization, protein processing, and signaling behavior. Despite these changes, SLC45A3 expression is often retained in prostate tumors, indicating preservation of key aspects of epithelial identity and secretory activity. Detection of Prostein can therefore provide insight into both normal and disease-associated epithelial function.
Prostein Antibody clone SLC45A3/7650 enables investigation of secretory epithelial biology by allowing visualization of Golgi-associated protein distribution and assessment of intracellular trafficking dynamics. Its strong association with secretory function, combined with prostate-specific expression and defined subcellular localization, makes it a valuable tool for studying epithelial physiology, protein processing pathways, and functional organization within prostate tissue.
Optimal dilution of the Prostein Antibody / Secretory Epithelial Cell Function Antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the Prostein Antibody / Secretory Epithelial Cell Function Antibody.
Aliquot the Prostein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
SLC45A3 antibody, Prostein antibody, Secretory epithelial marker antibody, SLC45A3 secretory protein antibody, Prostate secretory cell antibody
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