- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Prostate Specific Antigen Antibody Recombinant MAb / PSA KLK3 Antibody [clone rKLK3/6947] (V4646)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4646-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4646-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4646SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rKLK3/6947 |
| Purity | Protein A/G affinity |
| UniProt | P07288 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Prostate Specific Antigen antibody is available for research use only. |
|
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Prostate specific antigen (KLK3) is a secreted serine protease encoded by the KLK3 gene and is a member of the kallikrein related peptidase family. The protein is widely known as Prostate specific antigen or PSA and is produced predominantly by luminal epithelial cells of the prostate gland. Prostate Specific Antigen Antibody Recombinant MAb (clone rKLK3/6947) recognizes PSA and enables detection of KLK3 expression in prostate tissues and prostate derived tumors in research applications examining prostate biology and cancer.
PSA functions as a chymotrypsin like protease that participates in the liquefaction of seminal coagulum following ejaculation. In the prostate gland, PSA is secreted into the luminal space of prostatic ducts and glands where it cleaves semenogelin and other seminal plasma proteins to maintain semen fluidity. The PSA protein is synthesized as a preproenzyme that undergoes signal peptide removal and proteolytic activation during secretion. Because PSA is produced almost exclusively by prostate epithelial cells, it is considered one of the most prostate specific proteins identified in human tissues.
In normal tissues, KLK3 expression is highly restricted to luminal epithelial cells lining prostatic glands. Within the prostate, PSA protein accumulates in the cytoplasm and luminal secretions of these epithelial cells. This tissue specificity has made PSA one of the most widely studied prostate associated proteins and an important marker for identifying prostate epithelial differentiation in biological research.
PSA expression is frequently retained in prostate adenocarcinoma and metastatic prostate cancer. Detection of KLK3 expression can therefore assist in studies investigating prostate tumor biology and the cellular origin of metastatic tumors. Evaluation of PSA expression patterns in prostate tumors and metastatic lesions provides insight into prostate cancer differentiation and tumor progression.
A recombinant monoclonal Prostate Specific Antigen antibody such as clone rKLK3/6947 provides a sensitive reagent for detecting PSA in research applications involving prostate tissue biology and tumor studies. Detection typically reveals cytoplasmic and luminal localization of PSA in prostate epithelial cells and prostate adenocarcinoma cells consistent with the secretory nature of the KLK3 protein.
Optimal dilution of the Prostate Specific Antigen Antibody Recombinant MAb clone rKLK3/6947 should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 150-250) from the human protein was used as the immunogen for the Prostate Specific Antigen antibody.
Aliquot the Prostate Specific Antigen antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
PSA antibody, KLK3 antibody, Kallikrein related peptidase 3 antibody, Human prostate specific antigen antibody
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