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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Progesterone Receptor Antibody Clone PR500 [clone PR500] (V2225)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V2225-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V2225-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V2225SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | PR500 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| Gene ID | 5241 (Human) |
| Localization | Nuclear, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 0.5-1ug/ml |
| Limitations | This Progesterone receptor antibody is available for research use only. |
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Progesterone receptor (PGR) is a ligand-activated nuclear hormone receptor encoded by the PGR gene that functions as a transcription factor regulating cellular responses to progesterone signaling. Progesterone Receptor Antibody Clone PR500 recognizes this steroid hormone receptor, also known as Nuclear receptor subfamily 3 group C member 3 (NR3C3), a member of the nuclear receptor superfamily that mediates hormone-dependent transcriptional regulation. Progesterone receptor is primarily localized in the nucleus where progesterone binding promotes receptor activation and recruitment to progesterone response elements that regulate gene transcription involved in reproductive biology and endocrine signaling.
Progesterone Receptor Antibody Clone PR500 is a mouse monoclonal antibody developed to detect the PGR protein in research studies investigating steroid hormone receptor biology. Clone PR500 recognizes Progesterone receptor and provides a tool for examining receptor expression and regulation in experimental systems used to study progesterone signaling pathways. Antibodies targeting Progesterone receptor are widely used in studies of hormone-responsive tissues and endocrine signaling mechanisms where progesterone-dependent transcriptional regulation plays a central role.
The PGR gene produces two principal receptor isoforms known as PR-A and PR-B, which arise from alternative transcription start sites and differ in their N-terminal regulatory regions. PR-B contains an additional transcriptional activation domain that enhances activation of progesterone-responsive genes, whereas PR-A can function both as a transcriptional activator and as a regulatory modulator of PR-B signaling activity. These isoforms contribute to the complex regulation of progesterone signaling and influence tissue-specific transcriptional responses to hormone stimulation.
Progesterone receptor signaling plays an important role in reproductive biology and endocrine regulation. Expression of PGR is commonly observed in hormone-responsive tissues including uterus, ovary, and mammary gland where progesterone signaling regulates processes such as ovulation, implantation, and mammary gland development. Progesterone receptor expression is also frequently examined in breast cancer research and in studies of other hormone-responsive tumors where steroid hormone signaling contributes to cellular proliferation and transcriptional control.
Progesterone Receptor Antibody Clone PR500 has been reported in a peer reviewed scientific publication investigating progesterone receptor biology and hormone-dependent signaling pathways. The presence of published research involving clone PR500 supports its use in experimental studies examining nuclear hormone receptor regulation, endocrine signaling mechanisms, and progesterone-dependent transcriptional control.
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
Recombinant human Progesterone Receptor protein was used as the immunogen for this Progesterone Receptor Antibody Clone PR500.
Store the Progesterone receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
PGR antibody, NR3C3 antibody, Progesterone receptor A antibody, Progesterone receptor B antibody, PR-A antibody
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