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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Profilin 2 Antibody / PFN2 (R31282)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31282 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P35080 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Immunofluorescence : 5ug/ml |
| Limitations | This Profilin 2 antibody is available for research use only. |
|
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Profilin 2 antibody targets Profilin 2, encoded by the PFN2 gene. Profilin 2 is a small actin-binding protein that belongs to the profilin family, which plays a central role in regulating actin cytoskeleton dynamics. Profilins bind monomeric actin and control its availability for polymerization, thereby influencing filament assembly, turnover, and organization. Profilin 2 is primarily localized in the cytoplasm, where it associates with actin-rich structures and participates in processes requiring rapid cytoskeletal remodeling.
Functionally, Profilin 2 regulates actin polymerization by facilitating the exchange of ADP for ATP on actin monomers and delivering actin to growing filament ends in coordination with other actin-associated proteins. In addition to actin binding, Profilin 2 interacts with polyproline-rich motifs found in numerous signaling and cytoskeletal proteins, linking actin dynamics to intracellular signaling pathways. Through these interactions, Profilin 2 contributes to cell shape control, motility, vesicle trafficking, and synaptic function. A Profilin 2 antibody supports studies focused on cytoskeletal regulation and actin-dependent cellular processes.
PFN2 expression is particularly enriched in the nervous system, where Profilin 2 plays important roles in neuronal development, synaptic plasticity, and neurotransmission. It is highly expressed in neurons and has been associated with dendritic spine morphology and activity-dependent remodeling of synapses. Compared with other profilin family members, Profilin 2 shows a more restricted expression pattern, underscoring its specialized functions in neural tissues. Expression is also detectable in other cell types that require tightly regulated actin dynamics.
From a disease-relevance perspective, Profilin 2 has been implicated in neurological disorders and neurodevelopmental abnormalities. Altered PFN2 expression or function has been associated with changes in synaptic structure and neuronal connectivity, and dysregulation of actin dynamics involving Profilin 2 has been studied in the context of neurodegenerative disease and synaptic dysfunction. Profilin 2 has also been investigated in cancer and cell migration studies, where actin remodeling is a critical determinant of invasive behavior.
At the molecular level, Profilin 2 is a highly conserved protein that interacts with actin, phosphoinositides, and proline-rich ligands to coordinate cytoskeletal responses to upstream signals. Post-translational modifications and binding partner availability can influence Profilin 2 activity and its association with actin networks, resulting in variable electrophoretic behavior on SDS-PAGE. A Profilin 2 antibody supports research applications focused on actin cytoskeleton biology, neuronal function, and disease-associated alterations in cell structure and signaling, with NSJ Bioreagents providing reagents intended for research use.
The stated application concentrations are suggested starting amounts. Titration of the Profilin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminus of human PFN2 (NKKAYSMAKYLRDSGF) was used as the immunogen for this Profilin 2 antibody (100% homologous in human, mouse and rat).
After reconstitution, the Profilin 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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